Objective
The precision and reproducibility of cellular processes poses a challenge to nonequilibrium many-body physics and our understanding of the physical principles that control the emergent properties of biological systems. Despite great experimental and theoretical progress in understanding the molecular nature of particular cellular components, we lack a framework for understanding how the interactions between these stochastic nonlinear elements result in reliable building blocks of life and information transmission. In fruit fly development, proteins sequentially turn on genes, the expression states of which lay out the blueprint for the segments of the insect’s body. A challenge to biophysics and developmental biology is to understand how the correct genes are turned on at the correct location in space and at the correct time during development to precisely produce and coordinate the numerous cell types present in the adult organism. I propose to study the general problem of how the molecular building blocks of the cell (proteins, genes) interact and result in a functional system on the specific example of early gene expression in fruit fly development.
Current genetic manipulations in fruit flies will allow for experimental validation of the proposed molecular networks. I will work closely with experimental geneticists and biophysicist to understand the coordinated spatio-temporal expression of genes during development and describe their interactions in a quantitative manner. My broad goal is to extract global physical principles for the complex cellular interactions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries agriculture horticulture fruit growing
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
- natural sciences biological sciences zoology entomology
- natural sciences biological sciences biophysics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.