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Identifying genetic and microbial factors that promote intestinal inflammation and cancer using Drosophila

Objective

My long term goal is to establish a network of bacterial factors and the host signalling pathways they modulate in wild type and mutated intestinal cells that predispose for inflammation and cancer. The work of my future team will ultimately lead to a deeper understanding of critical aspects of intestinal human disease, including inflammatory bowel disease and the intestinal tumor formation and metastasis. To rapidly assess numerous combinations of inflammatory and anti-inflammatory host genes, bacterial species and their excreted factors we will use in this proposal Drosophila genetics and transcriptome analysis, chemical treatments and microbiological assays to identify the host and microbial factors that mediate inflammation and predispose for cancer using Drosophila. Despite the physiological divergence that exists between vertebrates and insects, modelling of human diseases is possible because of the high degree of conservation between Drosophila and mammalian signalling pathways controlling inflammation and infection.

Call for proposal

FP7-PEOPLE-2011-CIG
See other projects for this call

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Coordinator

UNIVERSITY OF CYPRUS
Address
Avenue Panepistimiou 2109 Aglantzi
1678 Nicosia
Cyprus
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 100 000
Administrative Contact
Evis Drousiotis (Mr.)