Objective My long term goal is to establish a network of bacterial factors and the host signalling pathways they modulate in wild type and mutated intestinal cells that predispose for inflammation and cancer. The work of my future team will ultimately lead to a deeper understanding of critical aspects of intestinal human disease, including inflammatory bowel disease and the intestinal tumor formation and metastasis. To rapidly assess numerous combinations of inflammatory and anti-inflammatory host genes, bacterial species and their excreted factors we will use in this proposal Drosophila genetics and transcriptome analysis, chemical treatments and microbiological assays to identify the host and microbial factors that mediate inflammation and predispose for cancer using Drosophila. Despite the physiological divergence that exists between vertebrates and insects, modelling of human diseases is possible because of the high degree of conservation between Drosophila and mammalian signalling pathways controlling inflammation and infection. Fields of science natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesclinical medicinegastroenterologyinflammatory bowel diseasemedical and health sciencesclinical medicineoncologynatural sciencesbiological scienceszoologyentomology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants" Call for proposal FP7-PEOPLE-2011-CIG See other projects for this call Funding Scheme MC-CIG - Support for training and career development of researcher (CIG) Coordinator UNIVERSITY OF CYPRUS Address Avenue panepistimiou 2109 aglantzi 1678 Nicosia Cyprus See on map Region Κύπρος Κύπρος Κύπρος Activity type Higher or Secondary Education Establishments Administrative Contact Evis Drousiotis (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data
