Objective Cytokinesis, the final step of cell division, has two crucial processes to achieve: equal sorting of cellular components between the daughter cells, and membrane ingression and closure. Both processes strongly rely on membrane components and properties. It is known that some lipids localize to the cleavage site and that membrane transport is required to relieve cortical tension during cytokinesis, which is necessary for the physical separation of cells. However, the precise role and mechanism of this essential membrane retrieval are unknown, as is the nature of the lipids and proteins involved, in part because it has been difficult to study the role of lipids in membrane organization due to a lack of appropriate tools. The goal of this multi-disciplinary proposal is to understand which lipids participate in cytokinesis and how cytokinesis and membrane transport interface. I will combine approaches from chemistry and chemical biology with cell biology and imaging to achieve this goal. My comprehensive and systematic investigation will provide new insights into the important question of how cells divide, which will not only be important for basic biology, but also for understanding how cell division is mis-regulated in diseases such as cancer. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencescell biologynatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsmedical and health sciencesclinical medicineoncology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants" Call for proposal FP7-PEOPLE-2011-CIG See other projects for this call Funding Scheme MC-CIG - Support for training and career development of researcher (CIG) Coordinator KING'S COLLEGE LONDON Address Strand WC2R 2LS London United Kingdom See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Daniel Walker (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data
