Skip to main content

A chemical approach to understanding the role of membranes and membrane transport in cell division

Objective

Cytokinesis, the final step of cell division, has two crucial processes to achieve: equal sorting of cellular components between the daughter cells, and membrane ingression and closure. Both processes strongly rely on membrane components and properties. It is known that some lipids localize to the cleavage site and that membrane transport is required to relieve cortical tension during cytokinesis, which is necessary for the physical separation of cells. However, the precise role and mechanism of this essential membrane retrieval are unknown, as is the nature of the lipids and proteins involved, in part because it has been difficult to study the role of lipids in membrane organization due to a lack of appropriate tools. The goal of this multi-disciplinary proposal is to understand which lipids participate in cytokinesis and how cytokinesis and membrane transport interface. I will combine approaches from chemistry and chemical biology with cell biology and imaging to achieve this goal. My comprehensive and systematic investigation will provide new insights into the important question of how cells divide, which will not only be important for basic biology, but also for understanding how cell division is mis-regulated in diseases such as cancer.

Field of science

  • /social sciences/social and economic geography/transport
  • /natural sciences/biological sciences/cell biology
  • /natural sciences/biological sciences/biochemistry/biomolecules/lipids

Call for proposal

FP7-PEOPLE-2011-CIG
See other projects for this call

Funding Scheme

MC-CIG - Support for training and career development of researcher (CIG)

Coordinator

KING'S COLLEGE LONDON
Address
Strand
WC2R 2LS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 100 000
Administrative Contact
Daniel Walker (Mr.)