Objective Cervical cancer (CC) is the second most common cause of cancer deaths in women worldwide. The main objective of the RAIDs project is to use this model system which is accessible to repeat biopsies to learn how to stratify patients into targeted therapies. The patients’ tumors will be classified into molecular subtypes based on their molecular profile by use of high-throughput technologies (sequencing, RPPA) combined with integrative bioinformatics analysis. Stratification is a learning process which will need constant readaptation. It will rely on prognostic and predictive biomolecular information gained from patients who will receive either standard therapy (the cognitive cohort) or patients who receive (first generation) targeted therapy. Bioinformatics will be an essential tool to allow integrative genome/proteome analysis and provide functional interpretation of the results at each step. Machine learning techniques will be used to select the most reliable biomarkers. These tools will be used to predict response to cc treatment or progression. Moreover, systems biology approaches will be used to unravel the gene regulatory networks and signaling pathways involved in the tumor progression and should be helpful to select predictive biomarkers and putative drug targets.Tumor material will be sampled before and following standard therapy or therapeutic HPV vaccination and/or novel targeted drug treatments. Clinical annotation by imaging methods as well as through biomarkers will have quality control procedures and relevant statistical models will be applied.RAIDS is a multidisciplinary approach integrating genomic studies, protein arrays, viral genotyping and immunohistochemical investigations on CC cells and tissues between academic clinical centers and SME’s .The project is expected to provide new tools for early diagnosis and targeted treatments exploited by SMEs and to accelerate innovation of CC therapy and improve quality of life. Fields of science natural sciencesmathematicsapplied mathematicsstatistics and probabilitymedical and health sciencesclinical medicineoncologycervical cancermedical and health scienceshealth sciencesinfectious diseasesDNA virusesnatural sciencescomputer and information sciencesartificial intelligencemachine learningnatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.1.2-1 - Development of technologies with a view to patient group stratification for personalised medicine applications Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator INSTITUT CURIE Address Rue d ulm 26 75231 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Maud Kamal (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 651 811,20 Participants (17) Sort alphabetically Sort by EU Contribution Expand all Collapse all AMSTERDAM BIOTHERAPEUTICS UNIT Netherlands EU contribution € 723 630,00 Address Louwesweg 6 1066EC Amsterdam See on map Activity type Research Organisations Administrative Contact Bastiaan Nuijen (Dr.) Links Contact the organisation Opens in new window SEQOMICS BIOTECHNOLOGIA KORLATOLT FELELOSSEGU TARSASAG Hungary EU contribution € 957 200,00 Address Vallalkozok utja 7 6782 Morahalom See on map Region Alföld és Észak Dél-Alföld Csongrád Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Attila Kereszt (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Keocyt SAS Participation ended France EU contribution € 0,00 Address Rue chauvelot 29 92240 Malakoff See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Christophe Pasik (Dr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 281 466,36 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Celia Farge (Ms.) Links Contact the organisation Opens in new window Website Opens in new window STICHTING ANTONI VAN LEEUWENHOEK ZIEKENHUIS Participation ended Netherlands EU contribution € 0,00 Address Plesmanlaan 121 1066CX Amsterdam See on map Activity type Research Organisations Administrative Contact Jan Van Den Ham (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 372 134,40 Address Dr molewaterplein 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Selma Selma Ablak-Ergisi (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window KLINIKEN ESSEN-MITTE EVANG. HUYSSENS-STIFTUNG/KNAPPSCHAFT GEMEINNUTZIGE GMBH Germany EU contribution € 28 936,95 Address Henricistrasse 92 45136 Essen See on map Activity type Higher or Secondary Education Establishments Administrative Contact Christian Kurzeder (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAET GREIFSWALD Germany EU contribution € 23 370,70 Address Domstrasse 11 17489 Greifswald See on map Region Mecklenburg-Vorpommern Mecklenburg-Vorpommern Vorpommern-Greifswald Activity type Higher or Secondary Education Establishments Administrative Contact Andrea Voelker (Dr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT ZA ONKOLOGIJU VOJVODINE-ONCOLOGY INSTITUTE OF VOJVODINA IOV Serbia EU contribution € 122 352,40 Address Put doktora goldmana 4 21204 Sremska kamenica See on map Activity type Research Organisations Administrative Contact Marina Popovic (Dr.) Links Contact the organisation Opens in new window Website Opens in new window TEO HEALTH SA Romania EU contribution € 6 810,00 Address Iuliu maniu 49 corp vechi 500019 Brasov See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eugeniu Banu (Dr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUTIA MEDICO-SANITARA PUBLICA INSTITUTUL ONCOLOGIC Moldova EU contribution € 60 645,00 Address Strada testemiteanu 30 2025 Chisinau See on map Activity type Research Organisations Administrative Contact Nina Samet (Dr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT GUSTAVE ROUSSY France EU contribution € 545 692,80 Address Rue camille desmoulins 39 94805 Villejuif See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Arnauld Forest (Mr.) Links Contact the organisation Opens in new window Website Opens in new window QUANTICSOFT SARL France EU contribution € 147 380,14 Address Rue du cherche midi 86 75006 Paris See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nicolas De Saint Jorre (Mr.) Links Contact the organisation Opens in new window AYMING France EU contribution € 265 965,16 Address Rue chaptal 114 92300 Levallois-perret See on map Region Ile-de-France Ile-de-France Hauts-de-Seine Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Maud Bossard (Dr.) Links Contact the organisation Opens in new window Website Opens in new window STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Netherlands EU contribution € 537 572,80 Address Plesmanlaan 121 1066 CX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Jan Van Den Ham (Dr.) Links Contact the organisation Opens in new window Website Opens in new window HANNOVER CLINICAL TRIAL CENTER GMBH Germany EU contribution € 231 834,49 Address Carl neuberg str 1 k 27 oe 9751 30625 Hannover See on map Activity type Higher or Secondary Education Establishments Administrative Contact Thomas Fink (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK France EU contribution € 42 840,00 Address 30 bd saint-jacques batiment b 75014 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Alicja Szofer-Araya (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window
