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Rapid Identification of Respiratory Tract Infections

Objective

Respiratory Tract Infections (RTIs) are caused by a variety of bacterial, viral, fungal and other pathogens. RTIs are major causes of morbidity and mortality in adults and children worldwide causing millions of deaths each year. RTIs affecting the lung parenchyma (pneumonia) can be classified into three main categories: Community Acquired Pneumonia (CAP); Hospital Acquired Pneumonia (HAP) which includes Ventilator Associated Pneumonia (VAP); and opportunistic pathogens causing pneumonia in immunosuppressed patients (Opportunistic RTIs or ORTIs). RTIs are difficult to diagnose accurately and current standard microbiological culture based tests are laborious and time consuming with a turnaround time to results > 30 hours. Thus, all ill patients presenting with CAP, HAP, VAP or ORTIs are initially treated empirically with antibiotics, without an accurate identification of the causative microorganism and associated antibiotic susceptibility profile. This leads to inappropriate use of antibiotics, which can increase patient morbidity and mortality. Therefore, there is a great need for rapid molecular diagnostics tests capable of identifying a large range of microorganisms and antibiotic resistances rapidly and accurately so that appropriate therapy can be instituted on first consultation. Accurate pathogen identification and resistance profiling is also important for the epidemiological surveillance of pneumonia. The aims of the RiD-RTI project are (through a unique partnership of SMEs, universities and hospitals from 4 countries) to develop and evaluate three diagnostics products for the rapid diagnosis of CAP, HAP/VAP and ORTIs, based on a novel “sample-in, answer-out” diagnostic platform. The diagnostics products will be designed to be ‘near patient’, reliable, cost-effective and user friendly allowing for the rapid (< 2 hrs) and accurate detection, identification, quantification (for selected targets) and molecular drug susceptibility testing of RTIs.

Call for proposal

FP7-HEALTH-2012-INNOVATION-2
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Coordinator

UCL Elizabeth Garrett Anderson Institute for Women’s Health
Address
Gower Street
WC1E 6BT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 584 920
Administrative Contact
Michael Browne (Mr.)

Participants (5)

MOBIDIAG OY
Finland
EU contribution
€ 1 529 800
Address
Tukholmankatu 8
00290 Helsinki
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Antti Ojala (Mr.)
GENEWAVE SAS
France
EU contribution
€ 1 827 180
Address
Rue Pierre Fontaine 4
91000 Evry
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Yann Marcy (Dr.)
NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
EU contribution
€ 926 364
Address
University Road
H91 Galway
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mari Vahey (Ms.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

Participation ended

France
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Alix Pillot (Ms.)
UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 129 473
Address
Euston Road 250
NW1 2PG London
Activity type
Research Organisations
Administrative Contact
Joe Mwanza (Mr.)