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Development and clinical trials of a new Software ENgine for the Assessment & Optimization of drug and non-drug Therapy in Older peRsons

Objective

The European population of older people with multiple chronic diseases (multimorbidity) is increasing steadily in tandem with the rising population of people aged ≥ 65 years. Older multimorbid people are at high risk of polypharmacy (PP), inappropriate prescribing (IP), adverse drug reactions (ADRs) and adverse drug events (ADEs). PP, IP, ADRs and ADEs in turn cause excessive drug costs and excess healthcare utilization; ADRs and ADEs also cause significant mortality. The current rapid rise in drug expenditure relating mostly to drug use by older people across Europe is not economically sustainable. In tandem with the drug therapy problems, there is underuse of non-drug therapies i.e. physiotherapy, occupational therapy, speech & language therapy, nutritional therapy, psychotherapy in the treatment of chronic diseases in this cohort. Optimal management of drug and non-drug therapy in older multimorbid persons usually requires specialist skill, but most doctors who treat older people do not have specialist training in Geriatric Medicine. To address these challenges, we propose to design and build a software engine (SENATOR) with the capacity to optimize therapy and simultaneously minimize ADRs, IP, PP and excessive cost. SENATOR will evaluate drug indications and contraindications, ADR/ADE risk and detect IP using validated criteria. SENATOR will identify cheapest drug brands to minimize cost. SENATOR will also recommend appropriate symptom-focused drug therapy and avoidance of drugs unlikely to be beneficial in frailer older people with low one year life expectancy. In addition, SENATOR will provide specific advice on appropriate non-drug therapies for individual patients. To test SENATOR’s efficacy, we will perform a multicentre RCT involving 1800 older multimorbid patients hospitalized with acute illness under the care of specialists other than geriatricians, using ADR incidence, medication appropriateness and drug/healthcare costs as the main outcome measures.

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
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Coordinator

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Address
Western Road
T12 YN60 Cork
Ireland

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
David O'connell (Dr.)
EU contribution
€ 1 758 126

Participants (12)

UNIVERSITEIT GENT
Belgium
EU contribution
€ 547 343
Address
Sint Pietersnieuwstraat 25
9000 Gent

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mirko Petrovic (Prof.)
CLANWILLIAM HEALTH LIMITED
Ireland
EU contribution
€ 584 994
Address
Citywest Business Campus Lake Drive 3094 Citywest
D24A365 Dublin

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Amit Gupta (Mr.)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 599 819
Address
Plaza Carlos Trias Bertran 7
28020 Madrid

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
José Ignacio Flores Nicolás (Mr.)
ISTITUTO NAZIONALE DI RIPOSO E CURA PER ANZIANI INRCA
Italy
EU contribution
€ 675 000
Address
Via Santa Margherita 5
60124 Ancona

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Activity type
Research Organisations
Administrative Contact
Maria Grazia Palermi (Dr.)
UNIVERSITY OF EAST ANGLIA
United Kingdom
EU contribution
€ 189 600
Address
Earlham Road
NR4 7TJ Norwich

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Debbie Graver (Mrs.)
LANDSPITALI UNIVERSITY HOSPITAL
Iceland
EU contribution
€ 525 024
Address
Eiriksgata 5
101 Reykjavik

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Adalsteinn Gudmundsson (Dr.)
HASKOLI ISLANDS

Participation ended

Iceland
EU contribution
€ 23 210,14
Address
Saemundargotu 2
101 Reykjavik

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anna Birna Almarsdottir (Prof.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation ended

Germany
EU contribution
€ 148 537,02
Address
Oskar Von Miller Ring 29
80333 Muenchen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Mrs.)
CLININFO S.A.
France
EU contribution
€ 85 300
Address
Rue De Gerland- Entree 7 99
69007 Lyon

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philippe Foerster (Mr.)
GRAMPIAN HEALTH BOARD
United Kingdom
EU contribution
€ 631 587
Address
Eday Road 2 Summerfield House
AB15 6RE Aberdeen

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Susan Ridge (Dr.)
SYDDANSK UNIVERSITET

Participation ended

Denmark
EU contribution
€ 3 944,70
Address
Campusvej 55
5230 Odense M

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulla Iversen (Mrs.)
ARTTIC
France
EU contribution
€ 166 462,14
Address
39 Rue Des Mathurins
75008 Paris

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Dietz (Dr.)