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Systems biology approaches to cervical pre-cancer and cancer

Objective

Currently cervical histology is the gold standard procedure in the field. However, there is a need for alternative approaches and specific biomarkers to aid objective CIN lesion grading and to identify true high grade cervical disease, especially in the advent of primary HPV screening and widespread HPV vaccination.
Panel of mRNA markers has been developed using systems biology and datamining tools and has demonstrated high specificity [93%] and sensitivity [88%] for detecting CIN 2-3 lesions. Clinical data supports its application as a cervical cancer grading biomarker as well. Our goal is to ascertain the utility of this novel panel and extend it using systems biology approaches with experimentally and computationally derived proteomic biomarkers in cervical pre cancer and cancer disease, for more accurate diagnosis of CIN disease. Toward that goal we establish a general framework for validation of proteomic biomarkers. This will be achieved by combining advanced technologies in a robust and time-effective way, including DNA array to protein array copying, Human Combinatorial Antibody Library of phage display and iRIfS, imaging Reflectometric Interference Spectroscopy technology. Systems biology approached would focus on both the existing and new markers and will use this framework rapid validation. Systems biology exploration of some specific pathways is justified by our previous data, that the CIN1/CIN2+ discrimination could be related to some given pathways.
The proposed approach potentially reduce costs of cervical clinical studies providing a reliable, quantitative, multi-content diagnostic approaches and results in reducing the number of colposcopic events. Cytology specimens will be of greater clinical utility and will result in earlier detection of disease. Molecular characterization of CIN lesions provides a basis for re-definition of histological categories.

Field of science

  • /medical and health sciences/basic medicine/physiology/cytology
  • /social sciences/sociology/social problems/ageism
  • /natural sciences/chemical sciences/analytical chemistry/spectroscopy
  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Address
College Green
2 Dublin
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 442 084
Administrative Contact
Deidre Savage (Ms.)

Participants (4)

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 454 440
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Melanie Baumann
Cellcall Kft.
Hungary
EU contribution
€ 1 033 460
Address
Roppentyu Utca 48
1139 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Miklós Nyíri (Mr.)
BIAMETRICS GMBH
Germany
EU contribution
€ 438 900
Address
Auf Der Morgenstelle 18
72076 Tubingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Guenther Proll (Dr.)
GENOID MOLEKULARBIOLOGIAI KUTATO, GYARTO ES EGESZSEGUGYI SZOLGALATO KFT

Participation ended

Hungary
Address
Roppentyu Utca 48
1139 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Csaba Jeney (Dr.)