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Adapting Breast Cancer Screening Strategy Using Personalised Risk
Estimation

Objective

While early detection of breast cancer by screening appears effective, many women derive little or no benefit from screening, due to the way it is currently organized: as a one-size-fits all approach irrespective of personalised risk factors. It is known, however, that some women are at a much higher risk of getting the disease than others, and that mammography is unsuitable for cancer detection in women with dense breasts. The aim of this project is to develop personalised methods to tailor breast cancer screening to the individual needs of the woman. We will propose methods to stratify women at the highest risk to MRI; those with intermediate risk and/or dense breasts to follow-on ultrasound. A risk model will be developed that includes both breast cancer risk and the risk of missing cancers in mammograms. In this model, breast density plays a key role, as one of the largest known risk factors and the factor making mammograms ineffective. Two SMEs focusing on breast density are involved, where academic partners bring unique databases with over 80,000 screening mammograms and associated risk profiles. These are essential for model development, and subsequently for the development of products that benefit all women. Personalised screening is only economically feasible if it is based upon cost-effective strategies. While current methods in breast MRI imaging and breast ultrasound are promising, more efficient protocols must be developed to use these modalities routinely in screening. With leading SMEs and clinical partners, screening procedures will be optimized by developing automated image analysis tools to guide workflow and quality assurance. More efficient MRI protocols will be investigated to reduce time and cost, while the use of novel MRI imaging sequences without intravenous contrast will be explored. Cost-effectiveness of the stratification models will be assessed by combining the risk model with cost and effectiveness of alternative screening strategies.

Field of science

  • /natural sciences/computer and information sciences/databases
  • /natural sciences/physical sciences/acoustics/ultrasound
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer

Call for proposal

FP7-HEALTH-2012-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 048 127,20
Administrative Contact
Nico Karssemeijer (Prof.)

Participants (9)

MEVIS MEDICAL SOLUTIONS AG
Germany
EU contribution
€ 796 125,60
Address
Caroline-herschel-strasse 1
28359 Bremen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thomas Pross (Mr.)
MATAKINA UK LIMITED
United Kingdom
EU contribution
€ 631 680,75
Address
Walnut Tree Close 1
CB6 2SQ Ely
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ralph Highnam (Dr.)
BIOMEDIQ AS
Denmark
EU contribution
€ 700 086,80
Address
Fruebjergvej 3
2100 Kobenhavn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Camilla Jørgensen (Ms.)
MEDIRI GMBH
Germany
EU contribution
€ 404 360
Address
Eppelheimer Str 13
69115 Heidelberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Johannes Gregori (Dr.)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 566 798,75
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Administrative Contact
Christoph Schulte (Mr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 687 413,60
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katherine Boylan (Dr.)
UNIVERSITAT DE GIRONA
Spain
EU contribution
€ 355 290,40
Address
Placa Sant Domenec 3
17004 Girona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Montserrat Estopà (Dr.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 263 095,20
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carla H Van Gils (Dr.)
INSTITUT JULES BORDET
Belgium
EU contribution
€ 155 565,20
Address
Rue Heger Bordet 1
1000 Bruxelles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marielle Sautois (Ms.)