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MODeling the EnviRonmental and human health effects of Nanomaterials (MODERN)

Objective

Nano-sized materials are a common element in many industrial processes mainly due to their unique properties that lead to the production of high technology products. The widespread use of nanotechnology requires the consideration of the environmental and human health risks that may result from the introduction of engineered nanoparticles (eNPs) into the environment. Although toxic effects for certain types of eNP have been recently reported, there is still a lack of knowledge about their possible long-term effects in biological systems.
The project focuses on the understanding of the processes governing the interactions of nanoparticles with biological systems and their associated mechanisms of toxicity, which are essential for eNP safety assessment. Information on the effects of well characterized eNPs will be obtained from literature and other data repositories. Targeted in vivo and in vitro experiments will be also carried out to overcome the limitations of data availability and for model validation. Computational methods will be applied to model both nanostructure-property relationships and the complex and highly non-linear nano-bio interactions and to diminishing the need for animal testing.
The main goal of MODERN is to establish new modeling approaches suitable for relating nanotoxicity with the intrinsic molecular and physicochemical properties of eNPs at environmental exposure levels and to implement safe-by-design nanoparticle design strategies. This implies three specific objectives: (i) To apply computational models for the characterization of the structural and physicochemical properties leading to QNPRs and safe-by-design strategies for eNPs; (ii) to develop in silico models (QNAR) of biological activity of eNPs in the body and in the environment; and (iii) to establish a categorization and hazard ranking protocol for eNPs based on structural similarity principles and in the analysis of their toxicological profiles.

Call for proposal

FP7-NMP-2012-SMALL-6
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Coordinator

UNIVERSITAT ROVIRA I VIRGILI
Address
Carrer De Escorxador
43003 Tarragona
Spain

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rosa Sola-Alberich (Dr.)
EU contribution
€ 268 515

Participants (6)

HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ
Germany
EU contribution
€ 191 999
Address
Permoserstrasse 15
04318 Leipzig

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Activity type
Research Organisations
Administrative Contact
Annette Schmidt (Ms.)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 132 000
Address
Nordre Ringgade 1
8000 Aarhus C

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lene Birksø Bødskov (Mrs.)
KEEMILISE JA BIOLOOGILISE FUUSIKA INSTITUUT
Estonia
EU contribution
€ 160 280
Address
Akadeemia Tee 23
12618 Tallinn

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Activity type
Other
Administrative Contact
Toomas Välimäe (Mr.)
UNIVERSITAET BREMEN
Germany
EU contribution
€ 145 025
Address
Bibliothekstrasse 1
28359 Bremen

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Flink
TARTU ULIKOOL
Estonia
EU contribution
€ 101 997
Address
Ulikooli 18
51005 Tartu

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kaido Tamm (Dr.)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Address
Franklin Street 1111 12 Floor
94607 Oakland Ca

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
David Avery (Mr.)