Objective "Nanotechnology is rapidly expanding. However, some types of engineered nanoparticles can be toxic for living organisms and exhibit negative impact on the environment. Thus, the design of new nanomaterials must be supported by a rigorous risk analysis. Following the recommendations by the EU REACH system and regarding ethical aspects, the risk assessment procedures should be performed with possible reduction of living animal use. The main objective of the NanoPuzzles project is to create new computational methods for comprehensive modelling the relationships between the structure, properties, molecular interactions and toxicity of engineered nanoparticles. The methods will be based on the Quantitative Structure - Activity Relationship approach, chemical category formation and read-across techniques. Those methods have been widely used in risk assessment of other groups of priority chemicals. But, because of some specific reasons, they can not be applied directly to nanoparticles. We will be developing novel methods within four complimentary areas (""puzzles""), namely: (i) evaluation of physico-chemical and toxicological data available for nanoparticles (NanoDATA), (ii) developing novel descriptors of nanoparticles' structure (NanoDESC), (iii) investigating interactions of nanoparticles with biological systems (NanoINTER), and (iv) quantitative structure - activity relationships modelling (NanoQSAR). Developed methods will be tested and verified for their technical viability by the collaborating industry representative. By implementing the NanoPuzzles methods, extensive animal testing would be significantly reduced. Moreover, the project will deliver the basis for categorising nanoparticles based on potential exposure, phys-chem, structural and toxicological properties. To maximise its impact, the project is going to cooperate with ModNanoTox, NanoTransKinetics, NanoSafety Cluster and NanoMedicine ETP." Fields of science medical and health sciencesmedical biotechnologynanomedicinenatural sciencescomputer and information sciencescomputational scienceengineering and technologynanotechnologynano-materials Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2012.1.3-2 - Modelling toxicity behaviour of engineered nanoparticles Call for proposal FP7-NMP-2012-SMALL-6 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIWERSYTET GDANSKI Address Ul. bazynskiego 8 80309 Gdansk Poland See on map Region Makroregion północny Pomorskie Trójmiejski Activity type Higher or Secondary Education Establishments Administrative Contact Tomasz Puzyn (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 228 500,00 Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Italy EU contribution € 227 200,00 Address Via mario negri 2 20156 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Maria Grazia Pezzoni (Ms.) Links Contact the organisation Opens in new window Website Opens in new window ETHNIKO IDRYMA EREVNON Greece EU contribution € 211 110,00 Address Vas konstantinou 48 11635 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Ioanna Petrohilou (Ms.) Links Contact the organisation Opens in new window Website Opens in new window LIVERPOOL JOHN MOORES UNIVERSITY United Kingdom EU contribution € 195 200,00 Address Rodney street 2 egerton court L3 5UX Liverpool See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Administrative Contact Andrew Young (Prof.) Links Contact the organisation Opens in new window Website Opens in new window INNOBALTICA SP ZOO Poland EU contribution € 114 800,00 Address Ul. trzy lipy 3 80 172 Gdansk See on map Activity type Research Organisations Administrative Contact Katarzyna Dembowska (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window
