Objective Degeneration of cartilage is a major cause of chronic pain, lost mobility and reduced quality of life for millions of European citizens. From a clinical point of view treatment to achieve cartilage regeneration (hyaline) and not only repair (fibrous) remains a great challenge. No clinical therapy is available that leads to healing of cartilage defects.Current cartilage implants cannot establish the hierarchical tissue organisation that appears critical for normal cartilage function. We hypothesise that a biomimetic zonal organisation is critical for implants to achieve cartilage regeneration.HydroZONES represents an interdisciplinary consortium that adopts a strategy to regenerate, rather than repair, articular cartilage based on the tissues zonal structure and function.HydroZONES will use advanced bioprinting technology for fabrication of 3D biofunctional hydrogel constructs, eventually mechanically reinforced by degradable polymer scaffolds, as biomimetic reconstitution of the zonal organisation of natural cartilage. Constructs will be optimized for cell-free application and also for combination with chrondrogenic cells (chondrocytes and/or MSC). Stringent in vitro and long term in vivo testing of the constructs will be employed that will yield a new clinical standard for pre-clinical testing.Cutting edge 3D tissue models and bioreactor technology will be used together with in silico modelling to develop a predictive in vitro assay and test system that will be validated against the in vivo data.Installation of a quality and regulatory affair management system, GMP production, accredited in vitro testing and involvement of clinical partners and companies with experience in clinical trials ensures that the best performing construct will be brought into an optimal position for entering clinical trials at project end. HydroZONES will thus advance the European Union as world leader in the field of joint cartilage regeneration. Fields of science engineering and technologyenvironmental biotechnologybioremediationbioreactorsnatural scienceschemical sciencespolymer sciencesmedical and health sciencesmedical biotechnologyimplants Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2012.2.2-1 - Biomaterials for improved performance of medical implants Call for proposal FP7-NMP-2012-LARGE-6 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT EU contribution € 2 609 470,00 Address Josef-schneider-strasse 2 97080 Wurzburg Germany See on map Region Bayern Unterfranken Würzburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Anne Von Thun (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (16) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSIDAD DE NAVARRA Spain EU contribution € 818 166,00 Address Campus universitario edificio central 31080 Pamplona See on map Region Noreste Comunidad Foral de Navarra Navarra Activity type Higher or Secondary Education Establishments Administrative Contact Cristina Patsouris (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSKLINIKUM HEIDELBERG Germany EU contribution € 858 097,00 Address Im neuenheimer feld 672 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Thomas Eisenhauer (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 458 254,00 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Linda Pialek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands EU contribution € 834 358,00 Address Heidelberglaan 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Pieter J. A. De Koning (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT UTRECHT Netherlands EU contribution € 1 272 998,00 Address Heidelberglaan 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Martin Geest (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN EV Germany EU contribution € 551 012,00 Address Hohe strasse 6 01069 Dresden See on map Region Sachsen Dresden Dresden, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Sandra Martinka (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUTO POLITECNICO DE LEIRIA Portugal EU contribution € 200 944,80 Address Rua general norton de matos 2411-901 Leiria See on map Region Continente Centro (PT) Região de Leiria Activity type Higher or Secondary Education Establishments Administrative Contact Raquel Pedro (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data QUEENSLAND UNIVERSITY OF TECHNOLOGY - QLD QUT Australia EU contribution No data Address George street 2 4001 Brisbane See on map Activity type Higher or Secondary Education Establishments Administrative Contact Michael Mcardle (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Participation ended Germany EU contribution € 146 521,20 Address Oskar von miller ring 29 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Birgit Fuchs (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MICHAEL HUBERT BARFUSS Germany EU contribution € 298 176,00 Address See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Barfuss (Mr.) Links Contact the organisation Opens in new window Total cost No data CELLCOTEC BV Participation ended Netherlands EU contribution € 300 000,00 Address Professor bronkhorstlaan 10d 3723MB Bilthoven See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Howard Miller (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING PROTOSPACE Netherlands EU contribution € 117 166,00 Address Nijverheidsweg 16 3534 AM Utrecht See on map Activity type Other Administrative Contact Desirée Gerritsen (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG Germany EU contribution € 134 762,00 Address Sanderring 2 97070 Wuerzburg See on map Region Bayern Unterfranken Würzburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Christian Gloggengiesser (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LIFETEC GROUP BV Netherlands EU contribution € 479 040,00 Address Kennedyplein 11 5611 ZS Eindhoven See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jurgen De Hart (Dr.) Links Contact the organisation Opens in new window Total cost No data POLYVATION BV Netherlands EU contribution € 498 851,00 Address Kadijk 7d 9747 AT Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Aukje Dullemond Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ARTTIC France EU contribution € 171 884,00 Address 39 rue des mathurins 75008 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Martin Dietz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data