CORDIS
EU research results

CORDIS

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Bioactivated hierarchical hydrogels as zonal implants for articular cartilage regeneration

Project information

Grant agreement ID: 309962

Status

Closed project

  • Start date

    1 January 2013

  • End date

    31 December 2017

Funded under:

FP7-NMP

  • Overall budget:

    € 13 243 737,61

  • EU contribution

    € 9 749 700

Coordinated by:

UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT

Germany

Objective

Degeneration of cartilage is a major cause of chronic pain, lost mobility and reduced quality of life for millions of European citizens. From a clinical point of view treatment to achieve cartilage regeneration (hyaline) and not only repair (fibrous) remains a great challenge. No clinical therapy is available that leads to healing of cartilage defects.
Current cartilage implants cannot establish the hierarchical tissue organisation that appears critical for normal cartilage function. We hypothesise that a biomimetic zonal organisation is critical for implants to achieve cartilage regeneration.
HydroZONES represents an interdisciplinary consortium that adopts a strategy to regenerate, rather than repair, articular cartilage based on the tissues zonal structure and function.
HydroZONES will use advanced bioprinting technology for fabrication of 3D biofunctional hydrogel constructs, eventually mechanically reinforced by degradable polymer scaffolds, as biomimetic reconstitution of the zonal organisation of natural cartilage. Constructs will be optimized for cell-free application and also for combination with chrondrogenic cells (chondrocytes and/or MSC). Stringent in vitro and long term in vivo testing of the constructs will be employed that will yield a new clinical standard for pre-clinical testing.
Cutting edge 3D tissue models and bioreactor technology will be used together with in silico modelling to develop a predictive in vitro assay and test system that will be validated against the in vivo data.
Installation of a quality and regulatory affair management system, GMP production, accredited in vitro testing and involvement of clinical partners and companies with experience in clinical trials ensures that the best performing construct will be brought into an optimal position for entering clinical trials at project end. HydroZONES will thus advance the European Union as world leader in the field of joint cartilage regeneration.
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Coordinator

UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT

Address

Josef-Schneider-Strasse 2
97080 Wurzburg

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 609 470

Administrative Contact

Anne Von Thun (Dr.)

Participants (16)

UNIVERSIDAD DE NAVARRA

Spain

EU Contribution

€ 818 166

UNIVERSITATSKLINIKUM HEIDELBERG

Germany

EU Contribution

€ 858 097

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 458 254

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

EU Contribution

€ 834 358

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 1 272 998

LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN EV

Germany

EU Contribution

€ 551 012

INSTITUTO POLITECNICO DE LEIRIA

Portugal

EU Contribution

€ 200 944,80

QUEENSLAND UNIVERSITY OF TECHNOLOGY - QLD QUT

Australia

GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Germany

EU Contribution

€ 146 521,20

MICHAEL HUBERT BARFUSS

Germany

EU Contribution

€ 298 176

CELLCOTEC BV

Netherlands

EU Contribution

€ 300 000

STICHTING PROTOSPACE

Netherlands

EU Contribution

€ 117 166

JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG

Germany

EU Contribution

€ 134 762

LIFETEC GROUP BV

Netherlands

EU Contribution

€ 479 040

POLYVATION BV

Netherlands

EU Contribution

€ 498 851

ARTTIC

France

EU Contribution

€ 171 884

Project information

Grant agreement ID: 309962

Status

Closed project

  • Start date

    1 January 2013

  • End date

    31 December 2017

Funded under:

FP7-NMP

  • Overall budget:

    € 13 243 737,61

  • EU contribution

    € 9 749 700

Coordinated by:

UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT

Germany