Skip to main content

Bioactivated hierarchical hydrogels as zonal implants for articular cartilage regeneration

Objective

Degeneration of cartilage is a major cause of chronic pain, lost mobility and reduced quality of life for millions of European citizens. From a clinical point of view treatment to achieve cartilage regeneration (hyaline) and not only repair (fibrous) remains a great challenge. No clinical therapy is available that leads to healing of cartilage defects.
Current cartilage implants cannot establish the hierarchical tissue organisation that appears critical for normal cartilage function. We hypothesise that a biomimetic zonal organisation is critical for implants to achieve cartilage regeneration.
HydroZONES represents an interdisciplinary consortium that adopts a strategy to regenerate, rather than repair, articular cartilage based on the tissues zonal structure and function.
HydroZONES will use advanced bioprinting technology for fabrication of 3D biofunctional hydrogel constructs, eventually mechanically reinforced by degradable polymer scaffolds, as biomimetic reconstitution of the zonal organisation of natural cartilage. Constructs will be optimized for cell-free application and also for combination with chrondrogenic cells (chondrocytes and/or MSC). Stringent in vitro and long term in vivo testing of the constructs will be employed that will yield a new clinical standard for pre-clinical testing.
Cutting edge 3D tissue models and bioreactor technology will be used together with in silico modelling to develop a predictive in vitro assay and test system that will be validated against the in vivo data.
Installation of a quality and regulatory affair management system, GMP production, accredited in vitro testing and involvement of clinical partners and companies with experience in clinical trials ensures that the best performing construct will be brought into an optimal position for entering clinical trials at project end. HydroZONES will thus advance the European Union as world leader in the field of joint cartilage regeneration.

Field of science

  • /engineering and technology/environmental biotechnology/bioremediation/bioreactor
  • /medical and health sciences/medical biotechnology/medical bioproducts/implants

Call for proposal

FP7-NMP-2012-LARGE-6
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Address
Josef-schneider-strasse 2
97080 Wurzburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 609 470
Administrative Contact
Anne Von Thun (Dr.)

Participants (16)

UNIVERSIDAD DE NAVARRA
Spain
EU contribution
€ 818 166
Address
Campus Universitario Edificio Central
31080 Pamplona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cristina Patsouris (Mrs.)
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 858 097
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Eisenhauer (Mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 458 254
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Pialek (Ms.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 834 358
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pieter J. A. De Koning (Dr.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 1 272 998
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Geest (Mr.)
LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN EV
Germany
EU contribution
€ 551 012
Address
Hohe Strasse 6
01069 Dresden
Activity type
Research Organisations
Administrative Contact
Sandra Martinka (Mrs.)
INSTITUTO POLITECNICO DE LEIRIA
Portugal
EU contribution
€ 200 944,80
Address
Rua General Norton De Matos
2411-901 Leiria
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Raquel Pedro (Dr.)
QUEENSLAND UNIVERSITY OF TECHNOLOGY - QLD QUT
Australia
Address
George Street 2
4001 Brisbane
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Mcardle (Mr.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Participation ended

Germany
EU contribution
€ 146 521,20
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Mrs.)
MICHAEL HUBERT BARFUSS
Germany
EU contribution
€ 298 176
Address
Schwester Zita Weg 11
52080 Aachen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Barfuss (Mr.)
CELLCOTEC BV

Participation ended

Netherlands
EU contribution
€ 300 000
Address
Professor Bronkhorstlaan 10D
3723MB Bilthoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Howard Miller (Mr.)
STICHTING PROTOSPACE
Netherlands
EU contribution
€ 117 166
Address
Nijverheidsweg 16
3534 AM Utrecht
Activity type
Other
Administrative Contact
Desirée Gerritsen (Ms.)
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany
EU contribution
€ 134 762
Address
Sanderring 2
97070 Wuerzburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Gloggengiesser (Mr.)
LIFETEC GROUP BV
Netherlands
EU contribution
€ 479 040
Address
Kennedyplein 11
5611 ZS Eindhoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jurgen De Hart (Dr.)
POLYVATION BV
Netherlands
EU contribution
€ 498 851
Address
Kadijk 7D
9747 AT Groningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Aukje Dullemond
ARTTIC
France
EU contribution
€ 171 884
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Dietz (Dr.)