Commercial feasibility of triggered liposomal drug delivery by means of MOdulated CHAnnels

Project Information

MOCHA

Grant agreement ID: 310627

Project closed

Start date 1 June 2012

End date 31 May 2013

Funded under

• Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 157 420,18

EU contribution € 146 433,00

Coordinated by

RIJKSUNIVERSITEIT GRONINGEN
Netherlands

Objective

The clinical use of most conventional therapies is limited either by insufficient therapeutic drug concentrations at the target tissue or the severe toxic effects of the drug on healthy tissues. The encapsulation of the drug into a liposome as a carrier and its selective delivery to the affected area is one of the solutions. Several liposomal drug formulations have been approved as anticancer therapeutics however, their clinical significance has been limited by slow passive release of the drug at the target site. The idea of ERC-PoC project is to incorporate an engineered ion channel into liposomes as a sensory valve for triggered release of the liposomal content at the target site. The unique advantage of this system is the ability to make liposomes responsive towards a signal with a sensitivity that is not possible to reach with current available systems. This makes the channels excellent candidates for use in drug carriers such as liposomes and exosomes for stimulus-induced drug release. This IP protected technology (two patents) has shown its technological feasibility in the ERC project. Within the ERC-PoC project we want to explore how we are able to enter the market by developing a sound business plan, IPR strategy, market assessment and a product development plan. The outcomes will be consolidated in a sound business plan that will be presented to venture capitalists or other strategic partners.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• natural sciences › biological sciences › cell biology

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Programme(s)

• FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• ERC-OA-2011-PoC - European Research Council ERC Proof of Concept

Call for proposal

ERC-2011-PoC
See other projects for this call

Funding Scheme

CSA-SA(POC) - Supporting action (Proof of Concept)

Host institution

RIJKSUNIVERSITEIT GRONINGEN

• EU contribution: € 146 433,00
• Address: Broerstraat 5 ; 9712CP Groningen ; Netherlands
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

Beneficiaries (1)

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

• EU contribution: € 146 433,00
• Address: Broerstraat 5 ; 9712CP Groningen
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data