Objective
This proposal describes single-molecule studies of gene-expression mechanisms and DNA nanodevices. The completion of the human genome project has propelled the scientific community to the next frontier of biomedicine: understanding the regulation of gene expression, i.e. how, where, and when genetic information on DNA is converted into functional proteins, and how gene expression is linked to organism development and disease.
Detailed studies of gene expression are usually precluded by excessive heterogeneity, large size, and transient nature of the gene-expression machinery. Such challenges are addressable by single-molecule methods, which remove the ensemble averaging of bulk methods and record real-time movies of single biomachines at work. I propose to study medically important gene-expression mechanisms using single-molecule spectroscopy equipped with alternating-laser excitation (ALEX), a method that I developed as a post-doctoral researcher at the University of California, Los Angeles (UCLA). I also propose to use ALEX-based spectroscopy to study the ability of DNA-based nanodevices to transport electrons and energy, thus contributing to an emerging field of Bionanotechnology with major scientific and technological implications.
All projects are high interdisciplinary, requiring expertise in physics, biophysics, chemistry, biochemistry, molecular biology, microbiology, statistics, and computer science, and thus offering an excellent opportunity for training the next generation of researchers in the field s of biotechnology and nanotechnology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences genetics RNA
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
OXFORD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.