Final Activity Report Summary - PLK1 INHIBITION (Inhibition of Cancer by Disrupting Interaction Between Polo-like Kinase 1 Polo-box Domain and Spindle Targets)
The Marie Curie grant enabled the researcher to start a new research theme - active compound testing in live mammalian cells and determination of therapeutic methods during drug design at the laboratory. The institute did not carry out research in this field prior to the scientist's return. Together with the help of EU structural funds and Lithuanian Science and Studies Foundation, new equipment and research reagents were purchased. Four permanent staff positions were established and supported by Lithuanian state budget. The scientist taught a number of personnel and students the methods of cell biology.
One of the main tasks of the scientist was to produce proteins-drug targets in prokaryotic and eukaryotic systems for the design of novel inhibitors that could become drug candidates with anticancer activities. As a result of the project, a group of novel inhibitors were designed, synthesised, and tested to be active against human cancerous cells. Two patent applications were submitted. Though numerous testing will be necessary before a drug candidate may be made, the beginning was successful, largely due to Marie Curie International Reintegration grant.