Objective
The goal of this project is to study the role of the nuclear receptor LXR (Liver X Receptor) in neuro-inflammation and neuro-degeneration. Nuclear receptors are ligand-dependent transcription factors capable of activating or repressing gene expression. Recent studies performed by the principal investigator at the University of California San Diego and by other groups have implicated LXR in the modulation of immune responses. The work proposed here will study whether LXR agonists exert effects on microglia activation, proliferation and programmed cell death in the context of neuro-inflammation.
One of the LXR target genes recently discovered by the principal investigator is an anti-apoptotic factor, AIM, specifically secreted by certain macrophage populations. W e are interested in determining whether LXR agonists promote release of this factor in the central nervous system and whether this pathway is relevant to protect neuronal cell death. By using gene expression profiling methodologies we will explore the transcriptional programs that are regulated by LXR in the context of neuro-inflammation. In vivo experiments in animal models of neuro-inflammation will provide an insight of whether LXR agonists may be used for therapeutic intervention of neuro-degenerative disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology multiple sclerosis
- medical and health sciences basic medicine immunology
- natural sciences biological sciences genetics RNA transcriptomes
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.