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From receptor to gene: structures of complexes from signalling pathways linking immunology, neurobiology and cancer

Objective

SPINE2-COMPLEXES (S2C) builds on SPINE successes (in establishing infrastructure and activity in HTP structural biology across Europe) to attack two of the central objectives of Structural Biology. Firstly, S2C will focus on systems of demonstrated biomedical relevance, almost entirely human proteins (plus some viral mimics). Secondly it will address the functional form of these proteins, complexes, interlinked in human signalling pathways of importance for human health. The S2C team is built upon a core of SPINE laboratories, selected on the basis of their enthusiasm to sign up to the concept of sharing work and pooling protein reagents within the Partnership to accelerate progress through cooperation. The new Partners include excellent young group leaders from the New Member States. Despite dramatic technological advances in HTP protein production there is an urgent need to develop specific technologies appropriate to S2C not covered by other FP6 grants (eg synchrotron technology is largely addressed by BIOXHIT).
Major technology developments will therefore be in protein production, especially HTP methods for eukaryotic expression, including co-expression, through refolding, to library based methods. The human signaling pathways targeted are
i) ubiquitination and de-ubiquitination
ii) cell cycle and apoptosis
iii) synaptogenesis and neuronal signalling
iv) kinases and phosphatases involved in signalling and regulation
v) transcriptional receptors and regulation
vi) innate and acquired immune receptors and inflammation and vii) viral subversion of cellular signalling and immune modulation.
These cellular processes frequently involve the same components and pathways, enhancing opportunities for inter-partner synergies. All Partners have signed up to joint target activity with at least one other Partner. Since S2C builds on SPINE we will be able to implement a transparent and effective management system, minimising the start-up time.

Call for proposal

FP6-2005-LIFESCIHEALTH-6
See other projects for this call

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Address
University Offices, Wellington Square
Oxford
United Kingdom

Participants (17)

WEIZMANN INSTITUTE OF SCIENCE
Israel
Address
Herzl Street
Rehovot
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
Heidelberg
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE - GROUPEMENT D'INTERET ECONOMIQUE
France
Address
1 Rue Laurent Fries
10142 Illkirch
KAROLINSKA INSTITUTET
Sweden
Address
Nobels Väg 5
Stockholm
UNIVERSITY OF YORK
United Kingdom
Address
Heslington
York
UNIVERSITEIT UTRECHT, FACULTY OF SCIENCES, DEPT. OF CHEMISTRY
Netherlands
Address
Heidelberglaan 8
Utrecht
THE NETHERLANDS CANCER INSTITUTE - ANTONI VAN LEEUWENHOEK HOSPITAL
Netherlands
Address
Plesmanlaan 121
Amsterdam
CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLOPROTEINE PARAMAGNETICHE
Italy
Address
Via Luigi Sacconi, 6
Sesto Fiorentino
EUROPEAN SYNCHROTRON RADIATION FACILITY
France
Address
6 Rue Jules Horowitz
220 Grenoble
MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE
Germany
Address
Robert-rossle-str. 10
740238 Berlin
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Serrano 117
Madrid
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
3 Rue Michel-ange
Paris
UNIVERSITE PARIS-SUD
France
Address
15 Rue Georges Clemenceau
Orsay
MTA ENZIMOLOGIAI KUTATOINTEZET
Hungary
Address
Karolina Ut 29-31
Budapest
USTAV MAKROMOLEKULARNI CHEMIE AKADEMIE VED CESKE REPUBLIKY
Czechia
Address
Heyrovskeho Nam. 2
Praha
DOMAINEX LTD
United Kingdom
Address
123 Old Brompton Road
London
INSTITUTO DE TECHNOLOGIA QUÍMICA E BIOLÓGICA
Portugal
Address
Av. De Republica, Estação Agronómica Nacional
Oeiras