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Improving HSCT By Validation Of Biomarkers & Development Of Novel Cellular Therapies

Objective

Novel transplant regimens are currently being developed to improve beneficial GvL effects and reduce GvHD and infections via several new forms of cellular therapies. This newly emerging supra-disciplinary field of cellular therapy and regenerative medicine is also being used to improve outcomes in autoimmune disease (such as Rheumatoid Arthritis) and cancers. The goal of this research programme is to gain insight into the mechanisms of action of GvL and GvHD in order to improve current therapies and develop and test novel ones via clinical trials and/or animal model experiments. The research is therefore necessarily multidisciplinary including clinical medicine, immunology, genomics, proteomics, molecular biology and pathology. In order to implement cellular therapies across Europe the current EU Directive 2001/83/EC applies. These regulations stipulate that the cellular therapies which are advanced therapeutic medical products (ATMP) must be produced under current Good Manufacturing Practice (cGMP). Not only is there a lack of understanding of GvL vs. GvHD effects but there is also a lack of training in cGMP for both clinical and non-clinical scientists. We aim to re-address these basic current needs, as well as those of industry, which include lack of access to clinical tissue for validation of bio-markers prior to commercialisation.

Field of science

  • /medical and health sciences/basic medicine/immunology/autoimmune diseases
  • /natural sciences/biological sciences/molecular biology
  • /medical and health sciences/clinical medicine/emergency medicine/graft versus host disease

Call for proposal

FP7-PEOPLE-2012-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

UNIVERSITY OF NEWCASTLE UPON TYNE
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 920 805,68
Administrative Contact
Helen Gallon (Mrs.)

Participants (10)

UNIVERSITETET I OSLO
Norway
EU contribution
€ 561 642,84
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Helene Mjelde (Ms.)
KLINIKUM DER UNIVERSITAET REGENSBURG
Germany
EU contribution
€ 222 068,88
Address
Frans Josef Strauss Allee 11
93053 Regensburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elisabeth Geiger (Ms.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 222 068,88
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Dittrich (Mr.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 240 201,72
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christoph Zielinski (Prof.)
UNIVERZITA KARLOVA
Czechia
EU contribution
€ 205 208,52
Address
Ovocny Trh 560/5
116 36 Praha 1
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Chlapec Jaromir (Mr.)
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
EU contribution
€ 222 068,88
Address
Robert-koch-strasse 40
37075 Goettingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christiane Hennecke (Ms.)
MILTENYI BIOTEC GMBH
Germany
EU contribution
€ 190 800,72
Address
Friedrich Ebert Strasse 68
51429 Bergish Gladbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Miriam Rode (Dr.)
ALCYOMICS LTD
United Kingdom
EU contribution
€ 250 652,16
Address
Bulman House Regent Centre
NE3 3 LS Newcastle Upon Tyne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anne Dickinson (Prof.)
MULTIMMUNE GMBH

Participation ended

Germany
Address
Arnulfstrasse 197
80634 München
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Claus Botzler (Dr.)
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 190 800,72
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Schaulin (Ms.)