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EpiHealthNet

Objective

Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life.
Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity for
newly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient delivery to the
needs of the developing fetus. EpiHealth will focus on these early events in several relevant models(diabetes, obesity and assisted
reproductive technologies (ART)),using human samples, stem cell lines, animal models and data mining/bioinformatics tools to decipher
some of the most important pathways and to offer options for early intervention to avoid adverse health effects. Main goal of the project is
to improve health of the human population by understanding the mechanisms and pathways in early development, with special emphasis
on epigenetic changes and developmentally relevant metabolic signalling, which create biological variation and have a long term effect on
the health of individuals across the lifespan. Specific goals include: i)Identification of the main genetic pathways affecting the health of the
developing embryos in a diabetic or obese maternal environment; ii) Identification of the main genetic and metabolic pathways affected and
epigenomic and imprinting perturbations from mouse and human ART resulting in altered health of the progeny; iii)Discovery of the key
genes and pathways affecting epigenetic and imprinting sensitivity in early stages of development in order to create intervention tools
against epigenetic mis-programming; iv)Linking for the first time by bioinformatics tools the longevity related pathways and those
susceptible to early epigenetic perturbations in order to explain how early events influence the health and lifespan of individuals; v)Studying
the possibilities of early intervention by controlling the maternal environment.

Call for proposal

FP7-PEOPLE-2012-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

UNIVERSITEIT UTRECHT
Address
Heidelberglaan 8
3584 CS Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 868 647,12
Administrative Contact
Marta De Ruijter-Villani (Dr.)

Participants (8)

BIOTALENTUM TUDASFEJLESZTO KFT
Hungary
EU contribution
€ 366 678,40
Address
Aulich Lajos Utca 26
2100 Goedoello
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ildiko Nagy (Dr.)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 285 606,64
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tom Fleming (Prof.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 572 313,28
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Ferguson-Smith (Prof.)
MARTIN-LUTHER-UNIVERSITAT HALLE-WITTENBERG
Germany
EU contribution
€ 222 618,88
Address
Universitatsplatz 10
6108 Halle
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peggy Patzner (Ms.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 285 606,64
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katherine Boylan (Dr.)
AVANTEA srl
Italy
EU contribution
€ 345 705,59
Address
Via Cabrini 12
26100 Cremona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Giovanna Lazzari (Dr.)
SZENT ISTVAN UNIVERSITY
Hungary
EU contribution
€ 395 061,04
Address
Pater Karoly Utca 1
2100 Godollo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andras Dinnyes (Prof.)
MWM BIOMODELS GMBH
Germany
EU contribution
€ 318 019,24
Address
Hauptstrasse 41
84184 Tiefenbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christian Simmet (Dr.)