Objective Prosthesis implantation of the hip and knee are amongst the most common operations carried out, together with the shoulder and finger prosthesis implantation these account for 1.4m operations annually across Europe. Although the prosthesis implants and equipment used for their implantation is sterilised post operative infections occur, resulting in 50000 cases of deep bone infection and 193000 cases of superficial infection. These infections are the result of bacterial contamination during the operation, once removed from the protective packaging, or of contamination of equipment. Deep bone infections often result in the removal of 7% of prosthesis implantations, in severe cases, 9% result in the amputation of the limb. Upon removal of the implantation the patient can be left without an implant for days or months until the infection has been eradicated at which point revisional surgery is performed.Our idea:Develop a dendritic structured surface coating for prosthesis implants that will deliver antibiotics, anti- inflammatory, with bone promotional drugs to the potential sites of infection following implantation. It will be done by encapsulating the desired drugs in a polymer shell that will decompose at a set rate to give the desired drug release over a series of weeks or months. The polymer shells will be linked to each other and the implant surface by a series of opposing pole affinity bonds that will break down as a result of bio-chemical attack from the immune system resulting in the release of the polymer encapsulated drugs into the surrounding area, allowing both deep bone infection and soft tissue infection to be treated.Our aim: Develop a surface coating for prosthesis implants that will revolutionise the implant market by reducing the number of post operative infections by 60% allowing for a greater number of implantations to be performed without the need for remedial... Fields of science medical and health sciencesclinical medicineodontologydental implantologynatural scienceschemical sciencespolymer sciencesengineering and technologymaterials engineeringcoating and filmsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsmedical and health sciencesmedical biotechnologyimplants Programme(s) FP6-SME - Horizontal research activities involving SMEs: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) SME-1 - Co-operative Research (all areas of science and technology) Call for proposal FP6-2004-SME-COOP See other projects for this call Funding Scheme COOPERATIVE - Coordinator FINSBURY DEVELOPMENT LTD Address 13 mole business park Leatherhead, surrey United Kingdom See on map Links Website Opens in new window EU contribution No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all TEKNIMED SA France EU contribution € 0,00 Address 8 rue de corps franc-pommies bp60 Vic en bigorre See on map Links Website Opens in new window Other funding No data BRACE GMBH Germany EU contribution € 0,00 Address Taunusring 50 Alzenau See on map Links Website Opens in new window Other funding No data HUNT DEVELOPMENTS (UK) LTD United Kingdom EU contribution € 0,00 Address Units 15-18 holmbush industrial estate Midhurst, west sussex See on map Links Website Opens in new window Other funding No data MEDICOAT AG Switzerland EU contribution € 0,00 Address Almuesenacherstrasse 2a Magenwil See on map Links Website Opens in new window Other funding No data PERA INNOVATION LIMITED United Kingdom EU contribution € 0,00 Address Pera innovation park, nottingham road Melton mowbray, leicestershire See on map Other funding No data GOTEBORGS UNIVERSITET Sweden EU contribution € 0,00 Address Vasaparken 100 Goteborg See on map Links Website Opens in new window Other funding No data BIOMATECH SA France EU contribution € 0,00 Address Z.i. de i'lslon, 115 rue de pasteur Chasse sur rhone See on map Links Website Opens in new window Other funding No data
