Objective
Prosthesis implantation of the hip and knee are amongst the most common operations carried out, together with the shoulder and finger prosthesis implantation these account for 1.4m operations annually across Europe. Although the prosthesis implants and equipment used for their implantation is sterilised post operative infections occur, resulting in 50000 cases of deep bone infection and 193000 cases of superficial infection. These infections are the result of bacterial contamination during the operation, once removed from the protective packaging, or of contamination of equipment. Deep bone infections often result in the removal of 7% of prosthesis implantations, in severe cases, 9% result in the amputation of the limb. Upon removal of the implantation the patient can be left without an implant for days or months until the infection has been eradicated at which point revisional surgery is performed.
Our idea:Develop a dendritic structured surface coating for prosthesis implants that will deliver antibiotics, anti- inflammatory, with bone promotional drugs to the potential sites of infection following implantation. It will be done by encapsulating the desired drugs in a polymer shell that will decompose at a set rate to give the desired drug release over a series of weeks or months. The polymer shells will be linked to each other and the implant surface by a series of opposing pole affinity bonds that will break down as a result of bio-chemical attack from the immune system resulting in the release of the polymer encapsulated drugs into the surrounding area, allowing both deep bone infection and soft tissue infection to be treated.
Our aim: Develop a surface coating for prosthesis implants that will revolutionise the implant market by reducing the number of post operative infections by 60% allowing for a greater number of implantations to be performed without the need for remedial...
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine odontology dental implantology
- medical and health sciences clinical medicine surgery
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences medical biotechnology implants
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-SME-COOP
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LEATHERHEAD, SURREY
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.