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Logical re-routing of cellular communication networks by DNA origami nanorobot

Objective

Almost every aspect of higher organism biology such as metabolism, growth and immunity, is regulated by intricate communication networks between multiple cell types. The ability to skew or interfere with these networks could lead to new ways to alleviate diseases caused or maintained by the interacting cells. However, since these cells are often dispersed across the entire organism, precise modulation of a single communication line is very challenging. In this project I propose to achieve this goal by DNA origami nanorobots programmed as routing devices for cell-cell communication. Each nanorobot is programmed to collect and sequester a specific type of signal molecule (cytokine, hormone etc.), and deliver it exclusively to a specific type of cell. Once programmed, a large group of nanorobots (~1016) effectively controls the traffic of signal molecules within an entire network, rendering it susceptible to arbitrary manipulations. These include re-routing signals to different cell addresses, up- or down-tuning the traffic volume in the path, or preventing a specific cell type from transmitting and receiving signals. This technology presents an advanced working draft towards automated biology as a strategy to solve challenges such as food, sustainable energy, emerging diseases etc.

Field of science

  • /engineering and technology/environmental engineering/energy and fuels/renewable energy

Call for proposal

FP7-PEOPLE-2012-CIG
See other projects for this call

Funding Scheme

MC-CIG - Support for training and career development of researcher (CIG)

Coordinator

AUGMANITY NANO LTD
Address
8 Hamada St
7670308 Rehovot
Israel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 54 166,67
Administrative Contact
Almogit Abu-Horowitz (Dr.)

Participants (1)

BAR ILAN UNIVERSITY

Participation ended

Israel
EU contribution
€ 45 833,33
Address
Bar Ilan University Campus
52900 Ramat Gan
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Estelle Waise (Ms.)