Objective
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and pneumonia in infants and the elderly worldwide. Despite that, there is no licensed RSV vaccine and only limited therapeutics exists. RSV primarily infects epithelial cells of the respiratory tract and replicates in the cytoplasm. Viral proteins traffic to the apical cell surface where they assemble into virus filaments and bud. However, the mechanism of virus filament formation and budding is poorly understood, neither is the role of viral filaments versus the budded virus. Budding is an essential step in the life cycle of all enveloped viruses; however, the way by which viruses complete the process and free themselves from the plasma membrane presents a biophysical problem. A great number of viruses were shown to recruit the host’s cellular ESCRT fission pathway. Nevertheless, it has been demonstrated that RSV budding is independent of the ESCRT pathway and therefore studies of RSV have the potential to reveal a new paradigm for membrane fission and virus release. The proposed research focuses on the viral and cellular requirements during RSV assembly and budding. The minimal RSV viral proteins essential for filament formation and budding are fusion (F), matrix (M), nucleoprotein (N), and phosphoprotein (P), therefore all of the above will be used for screening against the human proteome. The screen will eventually lead to cellular protein linking RSV to host machinery utilized for its assembly and release. In parallel, RSV mutants that differ in assembly and budding efficiency compared to WT due to impaired binding to cellular factor will be identified. The new interactions discovered will lead to better understanding the mechanism behind RSV assembly and budding and will shed light on alternative mechanisms of viral release. The ultimate outcome of my research will be generating attenuated RSV for future vaccine development and discovering new targets for antiviral drugs industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases RNA viruses
- medical and health sciences clinical medicine pneumology
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antivirals
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.