Final Report Summary - NPINMUPSS (Separation of Nanoparticles (NP) in Multiphase Systems (MuPSs))
Chiral mixed ligand silver nanoclusters were synthesized in the presence of a chiral and an achiral ligand. The ratio of the ligands was changed to track the formation of these clusters. While the chiral ligand lead to nanoparticles, presence of the achiral ligand induced the formation of nanoclusters with chiral properties. This work is one of the pioneer studies in the field of chiral nanoclusters that uses binary ligands to ensure the chirality. Synthesis and reporting of this type of clusters will potentially open up new venues in sensing.
In this project, we show the synthesis and characterization of chiral silver nanoclusters that are stabilized with a mixed ligand system: L-cysteine (L-cys) and mercaptohexanoic acid (MHA) (Scheme 1). In the reaction conditions that are tested, the use of MHA was critical for the formation of chiral nanoclusters compared to homoligand L-cys-stabilized silver nanoparticles. A nanocluster of ~10 kDa was consistently encountered even at different starting ligand ratios suggesting the stability of the complex of metals atoms with the ligands.
We systematically changed i) ligand and ii) silver to thiol ratio to determine the matrix of conditions that produce clusters. After the separation of reaction product at every synthesis through polyacrylamide gel electrophoresis (PAGE), we encountered with a specific dominant nanocluster. We characterized the optical properties of this cluster through UV-Vis and circular dichroism spectroscopy. We determined the mass of this previously unreported cluster to be in the range of 9.27 kDa and 10.68 kDa.
In conclusion we synthesized chiral nanoclusters with a binary ligand system. We observed that formation of nanoclusters is linked to the presence of the achiral ligand, MHA, whereas the chirality results from the presence of L-Cys. Additionally, regardless of ligand ratio, in most of the binary ligand systems we observed the formation of a chiral nanocluster with similar chemistry.
Dr. Ozge Akbulut, is an assistant professor in Sabanci University since the beginning of 2012. In this permanent position, her laboratory focuses on rheology modifiers for ceramic/metallic suspensions and silicone-based composites. She also founded a company, Surgitate, on tactile surgical training platforms, in 2014. She has four published articles and two EU patent applications since her new post. She is the recipient of “Young Investigator Award” and “New Ideas and Products Support Grant” from the Scientific and Technological Research Council of Turkey (TUBITAK). Her company also received Entreprenurship Seed Grant from TUBITAK and became the first company to receive funding from ARYA Women’s Investment Platform. Her active international collaborations span from EPFL, KAUST, and to the University of Edinburgh.
In this project, we show the synthesis and characterization of chiral silver nanoclusters that are stabilized with a mixed ligand system: L-cysteine (L-cys) and mercaptohexanoic acid (MHA) (Scheme 1). In the reaction conditions that are tested, the use of MHA was critical for the formation of chiral nanoclusters compared to homoligand L-cys-stabilized silver nanoparticles. A nanocluster of ~10 kDa was consistently encountered even at different starting ligand ratios suggesting the stability of the complex of metals atoms with the ligands.
We systematically changed i) ligand and ii) silver to thiol ratio to determine the matrix of conditions that produce clusters. After the separation of reaction product at every synthesis through polyacrylamide gel electrophoresis (PAGE), we encountered with a specific dominant nanocluster. We characterized the optical properties of this cluster through UV-Vis and circular dichroism spectroscopy. We determined the mass of this previously unreported cluster to be in the range of 9.27 kDa and 10.68 kDa.
In conclusion we synthesized chiral nanoclusters with a binary ligand system. We observed that formation of nanoclusters is linked to the presence of the achiral ligand, MHA, whereas the chirality results from the presence of L-Cys. Additionally, regardless of ligand ratio, in most of the binary ligand systems we observed the formation of a chiral nanocluster with similar chemistry.
Dr. Ozge Akbulut, is an assistant professor in Sabanci University since the beginning of 2012. In this permanent position, her laboratory focuses on rheology modifiers for ceramic/metallic suspensions and silicone-based composites. She also founded a company, Surgitate, on tactile surgical training platforms, in 2014. She has four published articles and two EU patent applications since her new post. She is the recipient of “Young Investigator Award” and “New Ideas and Products Support Grant” from the Scientific and Technological Research Council of Turkey (TUBITAK). Her company also received Entreprenurship Seed Grant from TUBITAK and became the first company to receive funding from ARYA Women’s Investment Platform. Her active international collaborations span from EPFL, KAUST, and to the University of Edinburgh.
