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Closing the Loop between Understanding and Effective Treatment of the Basal Ganglia and their Disorders

Final Report Summary - CLUE-BGD (Closing the Loop between Understanding and Effective Treatment of the Basal Ganglia and their Disorders)

The basal ganglia are major hub in the central nervous system. Disorders of the basal ganglia affect up to 10% of the population worldwide.
Nevertheless, current treatments of major basal ganglia disorders, including Parkinson's disease, depression and schizophrenia still fail in the long term.

The CLUE-BGD project had combined novel theoretical and experimental approaches to study the physiology of the basal ganglia and of their disorders. We have developed new ways of deep brain stimulation (DBS) via frequency and phase specific closed-loop adaptive DBS procedures. Hence, the CLUE-BGD project has paved the way for better treatment of many patients with severe basal ganglia disorders.

The basal ganglia are major hub in the central nervous system. Neurological and psychiatric disorders of the basal ganglia affect up to 10% of the population worldwide. Nevertheless, current treatments of major basal ganglia disorders, including Parkinson’s disease, Obsessive compulsive disorder (OCD), major depression and schizophrenia still fail in the long run.

The CLUE-BGD project has combined novel theoretical and experimental approaches to study the physiology of the basal ganglia and their disorders. We have shown that brain beta oscillations can be divided to short normal ones, and long pathological ones. The long episodes of beta oscillations are correlated with the akinesia of Parkinson’s disease, and probably with the depression, apathy and avolition of the psychiatric disorders. We have further shown that gamma oscillations dominate the basal ganglia activity in the non-human primate NMDA antagonist (ketamine, PCP) of schizophrenia

We have further developed new ways of deep brain stimulation (DBS) via phase specific closed loop adaptive DBS procedures. Stimulation at the falling phase of the beta oscillations make possible the suppression of pathological activity. On the other hand, stimulation at the rising phase of the oscillatory activity augment it.

Thus, combination of the frequency (long episodes of beta or gamma oscillations) and phase specific closed loop methods, would enable us to provide better treatment for both the neurological and the psychiatric disorders of the basal ganglia.