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ATP-sensitive potassium channels: from atomic structure to human disease


New structural insights into the gating movements of CFTR.

Author(s): Michael Puljung
Published in: Rockefeller University Press The Journal of General Physiology 2015
Permanent ID: Digital Object Identifier:10.1085/jgp.201511399,PubMed Central ID:PMC4411253,PubMed ID:25918357

An ABCC8 Nonsense Mutation Causing Neonatal Diabetes Through Altered Transcript Expression.

Author(s): Sian Ellard,Frances Ashcroft,Sarah Flanagan
Published in: Galenos Yayinevi Journal of Clinical Research in Pediatric Endocrinology 2017
Permanent ID: Digital Object Identifier:10.4274/jcrpe.4624,PubMed Central ID:PMC5596808,PubMed ID:28663158,urn:uri:b85e86af-3083-4f1e-a5a7-c4279a3ae4c3

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Author(s): Fiona Gribble,Patrik Rorsman,Frank Reimann,Ioannis Spiliotis,Reshma Ramracheya
Published in: Springer Science and Business Media LLC Nature Communications 2014
Permanent ID: Digital Object Identifier:10.1038/ncomms5639,PubMed Central ID:PMC4143961,PubMed ID:25145789,urn:uuid:cd9cf223-b5b0-49c6-988d-bdca21e4bf40,urn:uri:54b07831-5128-406b-bbe7-5aa7af26c057

Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice

Author(s): Gregor Sachse,Elizabeth Haythorne,Peter Proks,Michelle Stewart,Heather Cater,Sian Ellard,Ben Davies,Frances M. Ashcroft
Published in: Faculty of 1000 Ltd 2020
Permanent ID: Digital Object Identifier:10.12688/wellcomeopenres.15529.1

Binding of sulphonylureas to plasma proteins - A KATP channel perspective.

Author(s): Peter Proks,Holger Kramer,Elizabeth Haythorne,Frances M. Ashcroft
Published in: Public Library of Science (PLoS) PLoS ONE 2018
Permanent ID: Digital Object Identifier:10.1371/journal.pone.0197634,urn:uri:64ae6cbf-3b4d-4481-9e55-710f07246353,PubMed Central ID:PMC5957440,PubMed ID:29772022

Role of the C-terminus of SUR in the differential regulation of β-cell and cardiac KATP channels by MgADP and metabolism.

Author(s): Natascia Vedovato,Olof Rorsman,Konstantin Hennis,Frances M. Ashcroft,Peter Proks
Published in: John Wiley and Sons Inc. 2018
Permanent ID: Digital Object Identifier:10.1113/JP276708,PubMed Central ID:PMC6292810,PubMed ID:30179258

Functional identification of islet cell types by electrophysiological fingerprinting.

Author(s): Patrik Rorsman,Joely Kellard,Frances Ashcroft,Blanca Rodriguez
Published in: The Royal Society Journal of the Royal Society Interface 2017
Permanent ID: Digital Object Identifier:10.1098/rsif.2016.0999,PubMed Central ID:PMC5378133,PubMed ID:28275121,urn:uri:74b14b66-2a1e-4df7-981b-90a1733d1c4f