Objective
Schistosomiasis is an important parasitic disease in the developing world and is largely chronic in nature. Helminth infections, such as Schistosoma sp., often cause down-regulation of the adaptive immune response possibly through long-term, or repeated stimulation of the innate immune system following binding of parasite molecules to a limited number of innate receptors (e.g. Toll-like receptors). This aspect of the immune system represents a novel route to exploit in future control programs.
Therefore, our proposal has four objectives.
1. We will investigate differences in the innate immune response, specifically of innate receptors in groups of individuals with different histories of infection and extent of pathology, which will be further dissected in models of infection.
2 Glycan structures on molecules released by schistosomes are important candidate ligands of host innate receptors and so will be characterised, isolated and synthesised.
3 Isolated molecules will be tested using human in vitro assays and in vivo model systems, to identify those molecules with the greatest capacity to enhance or regulate immune responsiveness. These molecules bear promise as potential adjuvants in drug and vaccine control programmes, or as therapeutics to control pathology.
4 Finally, Geographical Information Systems will be applied to link features of the innate immune response to the history of exposure, and expression of pathology.
This framework will facilitate the implementation of drug and vaccine control programmes to those most at risk. The proposal is based upon a multidisciplinary and integrated consortium bringing together field based researchers (epidemiologists, health care workers), statisticians, and basic scientists (immunologists, biochemists) from 3 African and 3 European countries. Together, the partners will deliver an innovative project that will identify novel strategies that will aid the control of schistosomiasis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- humanities history and archaeology history
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-INCO-DEV-3
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
YORK
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.