Objective
Most catalytic reactions in Nature are mediated by enzymes. The concentrations of these enzymes are controlled in space and time through elaborate regulatory mechanisms, giving rise to complex functional behaviour that is essential to biology. Synthetic catalysts have been developed, many of which complement enzymatic catalysis with respect to types of reactions and substrate scope. Yet, in synthetic systems temporal control over catalyst concentrations remains underdeveloped, imposing limits on the functional potential. We reasoned that more elaborate control over synthetic catalysts may be achieved using a dynamic molecular network. Such networks have been mostly used for creating dynamic combinatorial libraries (DCLs). In dynamic combinatorial chemistry, a small set of building blocks react to form a combinatorial library of molecules that continuously exchange their building blocks, producing an equilibrium mixture. With the exception of applications in sensing, the objective of most DCL experiments is reductionistic: the identification of a single molecule with special properties. However, their network character makes DCLs potentially powerful tools for systems chemistry, where function derives from the entire network as opposed to an individual molecule. We now propose to apply the inherent dynamic nature of DCLs to several catalytic scenarios. The overall aim is to develop novel catalytic systems that exhibit some of the control mechanisms that have until now been exclusive to biology (i.e. responsiveness; feedback behaviour; regulation by signal molecules). Concretely, we aim to develop systems where the substrate induces the transient formation of its own catalyst, to develop systems in which catalysis is controlled by added effector molecules and to develop systems where catalysis shows feedback behaviour by the product of the reaction.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences catalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9712CP Groningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.