Objective
Growth and regeneration of complex tissues are emergent phenomena resulting from the cooperative action of many cells. Besides biological signaling, the geometry of the environment plays an important role in coordinating cell behavior, and determines the shape and structure of newly formed tissue. How precisely environmental geometries are able to control cell proliferation, differentiation and extracellular matrix deposition remains a challenge. In this project, a novel in vitro model platform will be developed to determine the interplay of external geometry and cell generated mechanical forces to direct multicellular tissue formation in 3D scaffold geometries. This approach integrates a quantitative growth assay using osteoblasts as cell model with leading-edge techniques for 3D substrate fabrication and molecular strain sensors. Matrix strains and stress fluctuations will be measured under systematically varying geometrical conditions while simultaneously monitoring proliferation and extracellular matrix production in order to test how mechanical parameters and cell behavior are correlated. The contribution of different mechanobiological mechanisms by which cells react to mechanical signals will be identified by selectively inhibiting cellular adhesion, contractility, and mechanotransduction pathways. The results of this project will not only shed light on the mechanisms behind osteoblast tissue deposition and bone remodeling, but also on the role of geometry and mechanics for tissue growth and regeneration in general. The Vogel lab at ETH Zurich has developed world leading techniques for molecular imaging of extracellular matrix strains, and for the fabrication of controlled cell environments. The combination of these techniques with the skills and expertise of the candidate will improve his potential to achieve professional maturity and provide a unique opportunity to increase the competitiveness of European science in the field of multicellular bioengineering.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- natural sciences mathematics pure mathematics geometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.