Objective
Breast cancer (BC) ranks second among cancer deaths in women. Each year, this disease is diagnosed in over one million women worldwide. Although progress has been made, we still do not understand the biology of BC at a level that would explain why certain patients react well to therapy, whereas for others the disease is recurrent, with an inexorable downhill course. This proposal focuses on the role of SHP2 and other protein tyrosine phosphatase (PTP) in BC metastasis and comprises three parallel approaches. The first aim is to address the roles of SHP2 in metastatic spread. The second assesses the merits of SHP2 as a therapeutic target in established BC metastases and the third will screen for other PTPs involved in metastatic BC. Virtually all cell signaling pathways are modulated by reversible protein tyrosine phosphorylation, which is regulated by two classes of enzymes, the protein tyrosine kinases (PTKs) and PTPs. Whereas the involvement of specific PTKs in BC has been well studied, the functions of specific PTPs in this disease are only now beginning to be elucidated. It has been discovered recently that SHP2 plays a fundamental role in tumor maintenance and progression in HER2-positive and triple-negative BCs, two subtypes associated with a poor prognosis. Importantly, SHP2 knockdown in established breast tumors blocked growth and reduced metastases. How does SHP2 knockdown in primary tumors reduce metastases? Can SHP2 inhibition in established metastases block their growth? Are other PTPs important for breast cancer metastases? To answer these questions, an intravital multiphoton microscope has been made for imaging fluorescently labeled metastatic BC cells expressing or lacking SHP2. These studies use state-of-the-art ex vivo and in vivo approaches to address the role of SHP2 and other PTPs in metastatic BC and should lead ultimately to the rational design of targeted therapies that will improve the clinical management of patients.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences physical sciences optics microscopy
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4056 BASEL
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.