Objective
"Dipeptidyl peptidase-4 (DPP-4) is an exoprotease that cleaves N-terminal dipeptides from several substrates such as glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GLP), impairing the function of the incretin system, which is of key importance for glucose homeostasis. Indeed, DPP4 inhibitors are currently in clinical use for type 2 diabetes. The host group has described for the first time that DPP4 is secreted by adipose and strongly correlates with adipocyte volume and parameters of the metabolic syndrome and is decreased to the lean level after weight reduction in humans. Moreover, novel data obtained in the host group suggest that DPP4 may impair insulin sensitivity in an auto- and paracrine manner. Thus, DPP4 arises as a novel adipokine potentially linking obesity to the metabolic syndrome. Since there is a growing interest in anti-diabetic therapies based on DPP4 inhibition, a deeper understanding of the role of adipose DPP4 on the onset and progression of insulin resistance is needed. This project aims to explore the impact of adipose DPP4 deletion in diet- induced obesity (ADDIO). For this purpose the host group is generating an adipose-specific DPP4 knockout mouse to prove a causal role
of this protein in the development of the metabolic syndrome. Our global aim will be pursued following a 3 step strategy: Firstly, we will assess the impact of adipose DPP4 genetic deletion by characterizing the metabolic phenotype of adipose-specific DPP4 knockout mice.
We will next determine the impact of genetic deletion of adipose DPP4 on the development of diet-induced impaired glucose tolerance and insulin resistance. Finally, we will explore the mechanism responsible for the potential protective/delaying effect of adipose DPP4 genetic deletion on impaired glucose tolerance and insulin resistance in obesity."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine physiology homeostasis
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
40225 Duesseldorf
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.