Objective
Phenylketonuria (PKU) is an inherited metabolic disease which, if left untreated, results in severe mental retardation. The main symptoms can be eliminated by following a restrictive and unpleasant diet, but it is unclear whether this diet should be maintained after childhood. The research team for TREPAPHEN is treating one of the largest cohorts of PKU patients in the UK with records of blood levels of Phe since infancy. These patients are the first generation to reach adulthood after treatment allowing, for the first time, assessment of whether, even in adulthood, high levels of Phe have a significant negative impact on brain functions and cognitive performance. TREPAPHEN will carry out an in-depth assessment of the cognitive performance of these patients in critical target areas and relate it not only to adult blood levels of Phe but also to measures of brain functions at different levels (structural, neurological and metabolic). The assessment of associations amongst cognitive, neurological and metabolic measures will enable an unprecedented level of understanding of this disorder, tracking the difficulties experienced by patients from the biological to the behavioural level. This will answer the question of whether or not adult patients should maintain a strict diet, a controversial policy issue across European Health Services. TREPAPHEN will bring together a talented young fellow, with a background in neuropsychology, an internationally excellent, interdisciplinary group with expertise in neuropsychological assessments, neuroimaging and clinical care of patients with metabolic disorders and a valuable cohort of patients with complete histories of Phe levels. Following this fellowship, the applicant will be an extremely sought after asset to European research with a unique set of skills in the theoretical understanding of cognitive impairments, their evaluation and the analysis of their biological correlates which can be used to study other patient groups.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
B4 7ET Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.