Objective
Sister chromatid cohesion is essential for proper chromosome segregation. Chromosome cohesion is mediated by cohesin complexes which form a ring-like structure that embraces replicated sister chromatids and hold them together until anaphase onset. Although cohesin binds to DNA dynamically before S phase, cohesion is only established during DNA replication, which requires acetylation of cohesin complexes and subsequent recruitment of Sororin. Sororin promotes cohesion establishment and cohesion maintenance from S phase until mitosis by antagonizing Wapl. Maintenance of chromosome cohesion is extremely important in mammalian meiosis. In oocytes, cohesion establishment occurs during pre-meiotic S phase, which takes place before birth, and then has to be stably maintained until completion of meiosis, which only occurs several months or years later during ovulation. The mechanism responsible for meiotic cohesin stabilization for such long periods of time remains unclear. Notably, the increase of trisomies and other birth defects with maternal age correlates with a gradual loss of sister chromosome cohesion during oocyte maturation. Here, we intend to study how chromosome cohesion is established and regulated during meiosis and to unravel the detailed mechanism responsible for maintenance of sister chromatid cohesion for very long periods of time. We will additionally study how the dynamics of meiotic cohesin complexes affect homologous pairing and meiotic recombination.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics heredity
- natural sciences biological sciences genetics chromosomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1030 Wien
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.