Objective
The extracellular matrix is a critical determinant of cell structure and function, and understanding cell-matrix interactions is area of significant current interest. However, characterizing the relationship between the matrix and cells is intractable in vivo; tools are not available to adequate manipulate matrix properties in a living organism. Thus the approach to addressing this problem that has emerged is based on engineered microenvironments, where advanced fabrication technologies from physics and engineering are used to build well-defined environments. But even with the many technical advances in this area, a unifying conceptual framework in which to present findings is lacking. For example, how does one compare the response of cells on surfaces with certain types of protein patterns to those on surfaces with specific topographic features? Here we propose to advance the state of the art in using advanced nanometer scale patterning and fabrication technologies to study the relationship between topographic signals and biochemical signals in controlling cellular responses. We propose to use focused ion beam milling to produce fibers that are organized similar to natural extracellular matrix, and combine these with patterns of proteins to which cells are known to respond. These data will then be analyzed using a novel information theoretic framework, using a spatial information metric (the k-space information). By varying the topographic and biochemical signals independently, we will establish how information from these two classes of signals interacts to modulate structural and functional responses of cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering fibers
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biophysics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
100 44 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.