Objective
The aim to make biological phenomena predictable is the driving force of research in systems biology. The ability to simulate entire cellular systems in the computer would be of great benefit for the biotechnological production of medication and the development of personalized medicine. To this end, the development of mathematical models plays a central role. The horizontal integration of models developed for gene regulation, signal transduction, or metabolism into a broader picture of the cellular interplay belongs to the most challenging problems of this endeavor: Models need to be combined that have solely been developed for one particular aspect. Only based on a holistic and detailed description of all cellular processes reliable computer models can be created by incorporating physico-chemical constraints that limit the model to experimental and real-world conditions. The creation of individual models is still not straightforward. Due to the complexity of the systems and the ability to simultaneously quantify several thousands of biological entities, this approach can only be feasible with the help of precise automated methods that reduce the human effort for model creation to a minimum. This project aims to unify the existing theoretical approaches for model creation (MASS and AMUSE). The effectiveness of these methods will be validated in an application to large-scale metabolic data (evolved E. coli, human erythrocytes and platelets). The combined wet-lab/dry-lab research facility at the University of California, San Diego, (UCSD) provides an excellent environment for the training of the applicant: Hands-on experimentation practice and effective large-scale study design involving biologists and modelers will be valuable learning objectives for the later establishment of independent research projects in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences health sciences personalized medicine
- natural sciences mathematics applied mathematics mathematical model
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
72074 Tuebingen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.