Objective
Many biological processes, with relevance to human development and disease, occur under the control of 'molecular clocks'. One such process is the rhythmical formation of somites during vertebrate embryogenesis. Somites are blocks of tissue that give rise to reiterated vertebrae and their associated muscle. The sequential formation of somites along the body axis of vertebrate embryos occurs via the activities of the vertebrate segmentation clock. My recent work has shown that the body units (segments) of an arthropod, the beetle Tribolium castaneum, also form via the activities of a segmentation clock. This finding suggests that vertebrate somites and arthropod segments form using similar developmental principles. Given the evolutionary distance separating vertebrates and arthropods this finding might also imply that a segmentation clock played an ancient and ancestral role in animal development. However, we have so far only identified two genes involved in the Tribolium clock, compared to 40-100 unrelated genes involved in the segmentation clocks of model vertebrates, making it too early to conclude that the arthropod and vertebrate segmentation clocks are evolutionarily related. I propose a series of genetic and genome-wide approaches to systematically test this idea. A novel, state-of-the-art, transcriptome screen will be used to determine the number and identity of genes involved in the Tribolium segmentation clock. Reverse genetic and transgenic approaches will be used to determine the regulatory interactions underlying the Tribolium clock. This constitutes an ambitious attempt to determine if the arthropod and vertebrate segmentation clocks are evolutionary related, knowledge that would have profound implications for our understanding of the evolution of all animals. It will also help establish Tribolium as a powerful invertebrate model for studying the principles underlying the activities of molecular clocks.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesevolutionary biology
- natural sciencesbiological sciencesdevelopmental biology
- medical and health sciencesclinical medicineembryology
- natural sciencesbiological scienceszoologyinvertebrate zoology
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Call for proposal
FP7-PEOPLE-2012-CIG
See other projects for this call
Coordinator
LS2 9JT Leeds
United Kingdom