Objective
"Mitosis is a critical phase of the cell cycle where chromosome are equally partitioned to daughter cells using the structure and forces from the mitotic spindle apparatus to power this process. The spindle is made of hundreds of dynamic microtubule polymers. Within the spindle, subpopulations of microtubules are tightly controlled by microtubule associated proteins and signaling gradients to achieve distinct properties and functions. Small perturbations to microtubules dynamics or these regulatory players can profoundly affect chromosome segregation and is associated with aneuploidy and genomic instability. Although many mitotic players have been identified, quantitative and mechanistic views of how they are regulated to control microtubule dynamics are missing. I propose to quantitatively define how different mitotic microtubule subpopulations are regulated in a space and time dependent manner. I have identified the kinetochore and centrosome-localized kinase Plk1 as a key factor in modulating microtubule dynamics. Using cell biology, advanced quantitative analysis and biochemistry, we will identify Plk1 substrates that modulate microtubule dynamics throughout mitosis. In addition, we will examine how a Plk1 locally regulates microtubules to create different microtubule populations. These studies will inform how genomic fidelity and chromosome segregation are ensured through maintaining accurate local and global microtubule dynamics."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- natural sciences chemical sciences polymer sciences
- natural sciences biological sciences genetics chromosomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
EH8 9YL Edinburgh
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.