Objective
Catalysts for stereoselective glycosylations will be developed. The focus being on designing organocatalysts for catalyst-controlled glycosylations.
Carbohydrates, the most abundant biomolecules on Earth, are intimately involved in many
crucial biological processes (signal transduction, cell recognition) and in diseases (AIDS,
cancer). They are useful for the investigation of diseases, and have great potential as vaccines
and therapeutics. The biology depends on the specific identity (including stereochemistry) of
the carbohydrates (usually oligosaccharides – several monosaccharides joined together).
A significant bottleneck in making scientific progress in the strategically important
field of glycoscience is the effort and expense required to synthesise pure oligosaccharides
and glycoconjugates as single stereochemical isomers. A major synthetic difficulty with
oligosaccharides (vs. oligonucleotides or oligopeptides) is the diversity that can exist: a rough
calculation suggests that there are ~256 DNA tetranucleotides, ~160,000 tetrapeptides and
>4x10^7 linear tetrasaccharides. Added permutations arise from the variety of monosaccharide
stereoisomers and the different connectivities possible at each linkage. Many oligosacchardies are not linear but branched - adding further permutations.
Given the impact of the ability to easily synthesise oligopeptides and oligonucleotides have had on modern biology, it is difficult to predict the impact of technology that would allow oligosaccharides to be synthesised with similar ease, other than that it would be highly significant. The proposal seeks to work towards this goal in a way that is complementary to approaches currently being used. Over the past 30 years stereoselective catalysis has transformed the availability of chiral molecules in enantiopure form. However, it has yet to make a similar impact on carbohydrate chemistry. GlyCat will be at the forefront of efforts to change the status quo in saccharide synthesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences chemical sciences catalysis
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
4 DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.