Objective
Disturbances in ion channel function lead to serious diseases of the nervous system, skeletal and cardiac muscle, and intestine which makes ion channels important drug targets for the pharmaceutical industry. Calcium currents through L-type voltage-gated C a2+ channels (L-VGCCs) play a key role in the cellular signalling in brain, heart, smooth muscles, sensory (e.g. inner ear, retina), and endocrine cells (e.g. pancreatic islets). In distinct cells of these organs, the pore forming 1-subunits Cav1.2 and/or Cav1.3 conduct Ca2+ currents that are required for their function. To address the important question about the differential contribution and functional communication of these L-VGCC isoforms and their potential role in other tissues an already existing net work of collaborating scientists will be complemented by excellent researchers providing the required advanced research methods and front-end ion channel expertise. As Cav1.2 and Cav1.3 show an overlapping expression pattern in a variety of tissues and sub unit-specific antagonists or agonists are not available so far, genetic tools are urgently needed to dissect the specific roles of both Cav1.2 and Cav1.3 in normal and pathological function. This consortium will complement its existing mouse models by new ones and will apply state of the art molecular biological, electrophysiological, Ca2+ imaging techniques and behavioural analyses to reveal the physiological role and pharmaco-therapeutic potential of these channels with a special focus on various diseases (e.g Alzheimer, epilepsy, arrhythmias, diabetes, tinnitus, deafness). The long standing and complementary expertise of the network partners will not only advance our understanding of the role of individual L-VGCC subtypes in health and disease but also provides an excellent opportunity for an integrative and interdisciplinary but appropriately focussed training in the field of signal transduction in general and ion channels in particular.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology epilepsy
- medical and health sciences clinical medicine cardiology cardiovascular diseases cardiac arrhythmia
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences medical biotechnology cells technologies stem cells
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
TUEBINGEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.