Objective
The EI-HCV Network will provide an integrated multidisciplinary and multi-sector training in a range of leading skills relevant to antiviral and immunotherapeutic drug development in the post-genomics era.
The researchers will gain world-class expertise in specialist shortage skills including structural biology, functional genomics (genomic analysis, bioinformatics, transcriptomics) and proteomics. They will also obtain training on a range of specialist instruments (e.g. DNA sequencers, confocal microscopes, gene arrays, mass specs, flow cytometers, bioinformatics clusters, synchrotrons, biophysical instruments etc.). This will be facilitated by an individual-focused and needs-driven structured training program encompassing in-house training, formal courses, workshops and major mobility elements such as training placements. Trainees will have the unique opportunity to be involved in a cross-sector project that will develop antivirals and immuno-therapies from the bench to the bedside. Specifically, the Network will identify new therapeutic interventions for the treatment of hepatitis C virus (HCV) infection.
Chronic HCV infection is frequently associated with severe liver disease including liver cancer. Even the latest treatments are ineffective in a significant proportion of infected individuals. Therefore there is a paramount need to identify new therapies. The Network will: Define HCV receptor binding, fusion and entry events; Determine the structure and functional regions of the HCV glycoproteins and receptors; Isolate and characterise neutralizing monoclonal antibodies and sera; Refine in vitro models to measure infectivity and antiviral effects; Use these advances to develop lead antiviral agents and immuno-therapies suitable for clinical trial.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesclinical medicineoncologyliver cancer
- medical and health scienceshealth sciencesinfectious diseasesRNA viruseshepatitis C
- natural sciencesphysical sciencesopticsmicroscopyconfocal microscopy
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals
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Keywords
Call for proposal
FP6-2005-MOBILITY-1
See other projects for this call
Funding Scheme
RTN - Marie Curie actions-Research Training NetworksCoordinator
NOTTINGHAM
United Kingdom