Objective
"Dendritic cells (DC) are professional antigen-presenting cells that represent an essential link between innate and adaptive immunity. While DC maturation is triggered by direct toll-like receptor engagement, it can also be initiated when DC interact with other cell types acting at the innate phase of the immune response like gamma delta T cells and natural killer (NK) cells. Gamma T cells can induce DC maturation and, when activated, induce the production of IL-12, an effect that involves gamma delta T cell-derived IFN-gamma. Interestingly, it has been recently shown that neonatal gamma delta T cells, in contrast to neonatal gamma delta T cells, are not deficient in IFN-gamma production. Also a cross-talk between DC and NK cells has been demonstrated. The primary objective is to identify strategies that might overcome the inability of neonatal DC to produce bioactive IL-12. This will contribute to the development of new adjuvants able to induce efficient Th1-type responses in human neonates. As it has been shown that IFN-gamma restores IL-12 production in neonatal DC, the focus will be to find cellular sources of IFN-gamma in human newborn. The primary candidates we will investigate are gamma delta T cells and NK cells. In a second line of research, we will t ry to identify new molecules involved in the maturation of the neonatal immune system via an unbiased approach, namely DNA microarrays. The expertise of the host institute (dendritic cells, neonatal immunology) clearly complements the background of David Vermijlen (human gamma delta T cells, NK cells, microarray experience) that will result in a synergistic effect and contribute to the scientific excellence of the European Union. In addition, David Vermijlen will return to Belgium, his country of origin, to become professionally integrated. Therefore, the proposed project fully meets the objectives of the Marie-Curie European reintegration grant."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences genetics DNA
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CHARLEROI (GOSSELIES)
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.