Objective
Radiation protection of low dose ionising radiation is currently based on linear extrapolation from high doses. Estimates of risk from radiation exposure are based on the mean exposure to a population. The effectiveness of radiotherapy (RT) for many tumours is dose limited to minimise late effects in normal tissue. Clinical observations of adverse effects indicate large variations in individuals. Strategies linking normal tissue and various phenotypical responses at high doses to predict individual risk of normal tissue response have not been successful.
The internationally leading, EU funded GENEPI-ENTB provides a valuable resource on normal tissue effects in a large cohort of RT patients. The objective is to couple analysis of cellular responses at low dose with the GENEPI bio-bank, providing an ideal opportunity to address whether differential genome-wide expression responses induced at low dose and inter-individual genetic differences are associated with the development of severe, normal tissue effects.
The team of leading European clinical and basic scientists will address the objective by concentrating on non-irradiated skin biopsies or T-cells from breast cancer patients in the GENEPI databank by:
i) identify two groups of patients (non- and over responders) who are statistically different in their normal tissue response to RT,
ii) taking into account national regulations, ethical guidelines and patient consent, non-irradiated skin biopsies and blood will be collected to establish fibroblast and T-cells and used to
iii) undertake genotyping and functional analysis after low dose and
iv) retrospective analyse for correlations between the genetic and functional findings to the severity of normal tissue responses.
The knowledge obtained from combining the data from approaches with the GENEPI bio-bank will contribute to better quantification of non-cancer health risks of radiotherapy and identify potential genetic components to environmental and medical exposure.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
EURATOM-2005-6-FIXEDDEADLINE
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BRUSSELS
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.