Objective
All tissues seem to contain a population of stem/ progenitor cells, which mediate normal repair. When this mechanism fails or is overwhelmed degeneration results and leads to disease. Mesenchymal stem cells (MSCs) can be isolated from adult tissues and are excellent candidates for regenerative medicine, which aims to repair damaged tissues at the cellular level. MSCs are self-renewing, able to differentiate into cells from multiple tissues and are the subject of at least 3 human clinical trials to evaluate t heir efficacy. However, the mechanisms controlling MSC proliferation and differentiation are not well understood. The work described in this proposal will investigate potential mechanisms by which MSCs regulate and accomplish their differentiation.
This study will compare the microRNA (miRNA) profiles of undifferentiated MSCs, differentiated MSCs and donor-matched control cells. MiRNAs are small RNAs that bind messenger RNAs affecting their translation and altering the protein complement of a cell. MiRNAs have been shown to regulate fundamental biological processes including differentiation of some stem cells, but to date no role has been described for miRNA in regulating MSC behaviour. An improved understanding MSC differentiation will improve MSC-based therapies, as well as raising the profile of European stem cell research. This will in turn improve European regenerative medicine, which will be of great economic importance as chronic degenerative conditions affect an increasing proportion of the population in aging Western societies.
Funding this proposal will aid the reintegration of an EU citizen who gained 10 years research experience in the US at prestigious research institutes and a Biotechnology company at the forefront of developing stem-cell based therapies. The applicant is returning to academic research in an Objective 1 area, the Borders and Western Region of Ireland, where she will be able to transfer her skills and knowledge to other researchers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
GALWAY
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.