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Multiparametric detection of bio-molecule conjugated nanoparticles for the diagnostic investigation of mycobacterial infections of humans and animals

Objective

WHO reports that tuberculosis results to millions of deaths or disabilities each year, especially in poorer areas of the planet. The problem is exacerbated by the AIDS epidemic that increases disease incidence in developed countries too. However in addition to tuberculosis, exposure to mycobacteria has also been linked to the pathogenesis of sarcoidosis and Crohn's disease that affect millions of people in Europe only. Diagnostic investigation of mycobacterial infections is hampered by the difficulty to detect in a specific manner low populations of mycobacteria or the immunology markers associated with the infections they cause. The NANOMYC project aims to develop a highly sensitive and specific, quantifiable detection system for molecular and immunology diagnostic markers associated with infection caused by M. tuberculosis complex (human and animal tuberculosis, implicated in sarcoidosis) and M. paratuberculosis (animal paratuberculosis, implicated in Crohn's disease). To this goal the consortium will combine nanotechnology and molecular biology incorporating the recent advances on the sequencing of mycobacterial genomes to routine diagnostics. Experts on mycobacteria genetics and nano-technology will produce a number of biomolecules that will be conjugated to a set of functionalized quantum dots with different oproelectrochemical characteristics. The NANOMYC assay will be developed in order to be applied for: a) in-field diagnostics using portable devices for evaluation of liquid samples, and b) manual and automated evaluation of solid samples using fluorescence resonance energy transfer. The final product will be a world innovation and it will target a market of several billion euro/year. Marketing of the NANOMYC assay will be used to sustain the project's administrative and financial platform and continue research activities in order to further the proposed technology for in-vivo diagnostic and therapeutic applications.

Call for proposal

FP6-2005-LIFESCIHEALTH-6
See other projects for this call

Coordinator

AGRICULTURAL UNIVERSITY OF ATHENS
Address
Iera Odos 75, Botanikos
Athens
Greece

Participants (9)

UNIVERSITY OF CRETE
Greece
Address
Knossou Avenue-ampelokipi-university Campus
Iraklion
UNIVERSITA DEGLI STUDI DI SASSARI
Italy
Address
Viale San Pietro 43B
Sassari
VINCA INSTITUTE OF NUCLEAR SCIENCES
Address
Mike Petrovica Alasa 12-14
Belgrade
EYGENIDION INFIRMARY AGIA TRIAS SA
Greece
Address
Papadiamantopoulou 20
Athens
BIOSURE RT CELL&CO
Greece
Address
Aglayroy 6, Koykaki
Athens
BIOTECGEN
Italy
Address
Viale Rossini, 3
Lecce
MEDIZONE GERMANY GMBH
Germany
Address
Lessing Str. 12
Munich
MALAMIS & MALAMIS CO
Greece
Address
Skoufa 52
Athens
ICOSAGEN AS
Estonia
Address
9 Nooruse Street
Tartu