Objective Heartwater or cowdriosis is a rickettsial disease of wild and domestic ruminants caused by Ehrlichia ruminantium. It occurs in sub-saharan Africa,Madagascar and the surrounding islands where the Amblyomma vectors are distributed. The disease is established in the Caribbean region where it threatens the American mainland. Anaplasma marginale,the agent of livestock anaplasmosis has a wider distribution. It has been identified on all continents where it is transmitted by ticks and biting flies. Both diseases are classified in list B of Office International des Epizooties. Their presence in a country is an obstacle to international trade of animals and losses induced constitute a major constraint to increased productivity of livestock. The objective of the project is to contribute to increased productivity of livestock by controlling the diseases in a context of sustainable production systems and environmental safety. To do so, integrated control is necessary where specific diagnostic and efficient vaccines are essential to reduce the use of acaricides which raise environment and food safety issues. This aim of the project is to deliver improved vaccines, diagnostic tests, risk mapping and economic analysis of vaccine control. Resuts will be obtained by extensive use of modern genomics: annotation, comparative and functional genomics of vector-pathogen interaction aiming to identify genes candidates. After refinement of the protective immune responses analysis, these candidates will be analysed in vitro and on ruminants for their ability to provide protection. New delivery systems and formulations will be applied to these candidates and evaluated for their ability to provide the best protection in a potential field vaccine. Meanwhile, molecular diagnostic (detection and genotyping) will allow us to establish a regional distribution and risk map to help decision-making in sanitary interventions and as a basis for cost-benefit studies of vaccination. Fields of science medical and health sciencesbasic medicineimmunologyimmunisationmedical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesagricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandrynatural sciencesbiological sciencesgeneticsgenomes Programme(s) FP6-INCO - Specific measures in support of international cooperation: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) INCO-2002-A3.1 - Health of livestock populations Call for proposal FP6-2002-INCO-DEV-1 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator CENTRE DE COOPERATION INTERNATIONAL EN RECHERCHE AGRONOMIQUE POUR LE DEVELOPPEMENT Address 42, rue scheffer Paris France See on map Links Website Opens in new window EU contribution € 0,00 Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE UNIVERSITY OF EDINBURGH United Kingdom EU contribution € 0,00 Address Old college, south bridge Edinburgh See on map Links Website Opens in new window UTRECHT UNIVERSITY Netherlands EU contribution € 0,00 Address Heidelberglaan 8 Utrecht See on map Links Website Opens in new window INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA Portugal EU contribution € 0,00 Address Av. da república - ean - qta. do marquês Oeiras See on map Links Website Opens in new window CENTRE DE RECHERCHE-DEVELOPPEMENT SUR L ELEVAGE EN ZONE SUB-HUMIDE Burkina Faso EU contribution € 0,00 Address 5-31 angle avenue du gouverneur louveau Bobo-dioulasso See on map Links Website Opens in new window MAKERERE UNIVERSITY Uganda EU contribution € 0,00 Address Makerere hill road Kampala See on map Links Website Opens in new window INTERNATIONAL TRYPANOTOLERANCE CENTRE The Gambia EU contribution € 0,00 Address No name Banjul See on map Links Website Opens in new window INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA Argentina EU contribution € 0,00 Address Los reseros y las cabañas Castelar buenos aires See on map Links Website Opens in new window AGRICULTURAL RESEARCH COUNCIL / ONDERSTEPOORT VETERINARY INSTITUTE South Africa EU contribution € 0,00 Address Old soutpan road Onderstepoort See on map Links Website Opens in new window INSTITUT SENEGALAIS DE RECHERCHES AGRICOLES Senegal EU contribution € 0,00 Address Route des hydrocarbures Dakar-hann See on map Links Website Opens in new window UNIVERSITÄT BERN Switzerland EU contribution € 0,00 Address Hochschulstr. 4 Bern See on map Links Website Opens in new window
