Objectif
Heartwater or cowdriosis is a rickettsial disease of wild and domestic ruminants caused by Ehrlichia ruminantium. It occurs in sub-saharan Africa,Madagascar and the surrounding islands where the Amblyomma vectors are distributed. The disease is established in the Caribbean region where it threatens the American mainland. Anaplasma marginale,the agent of livestock anaplasmosis has a wider distribution. It has been identified on all continents where it is transmitted by ticks and biting flies. Both diseases are classified in list B of Office International des Epizooties. Their presence in a country is an obstacle to international trade of animals and losses induced constitute a major constraint to increased productivity of livestock. The objective of the project is to contribute to increased productivity of livestock by controlling the diseases in a context of sustainable production systems and environmental safety. To do so, integrated control is necessary where specific diagnostic and efficient vaccines are essential to reduce the use of acaricides which raise environment and food safety issues. This aim of the project is to deliver improved vaccines, diagnostic tests, risk mapping and economic analysis of vaccine control. Resuts will be obtained by extensive use of modern genomics: annotation, comparative and functional genomics of vector-pathogen interaction aiming to identify genes candidates. After refinement of the protective immune responses analysis, these candidates will be analysed in vitro and on ruminants for their ability to provide protection. New delivery systems and formulations will be applied to these candidates and evaluated for their ability to provide the best protection in a potential field vaccine. Meanwhile, molecular diagnostic (detection and genotyping) will allow us to establish a regional distribution and risk map to help decision-making in sanitary interventions and as a basis for cost-benefit studies of vaccination.
Champ scientifique
- sciences médicales et de la santémédecine fondamentaleimmunologieimmunisation
- sciences médicales et de la santésciences de la santésanté publique et environnementaleépidémiologie
- sciences médicales et de la santémédecine fondamentalepharmacologie et pharmacieproduit pharmaceutiquevaccins
- sciences agricolessciences animales et liées à l'industrie laitièreanimaux domestiqueszootechnie
- sciences naturellessciences biologiquesgénétiquegénome
Appel à propositions
FP6-2002-INCO-DEV-1
Voir d’autres projets de cet appel
Régime de financement
STREP - Specific Targeted Research Project
Coordinateur
Paris
France
Voir sur la carte
Participants (10)
Edinburgh
Voir sur la carte
Utrecht
Voir sur la carte
Oeiras
Voir sur la carte
Bobo-dioulasso
Voir sur la carte
Kampala
Voir sur la carte
Banjul
Voir sur la carte
Castelar Buenos Aires
Voir sur la carte
Onderstepoort
Voir sur la carte
Dakar-hann
Voir sur la carte
Bern
Voir sur la carte