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Epidemiology and new generation vaccines for Ehrlichia and anaplasma infections of ruminants

Objectif

Heartwater or cowdriosis is a rickettsial disease of wild and domestic ruminants caused by Ehrlichia ruminantium. It occurs in sub-saharan Africa,Madagascar and the surrounding islands where the Amblyomma vectors are distributed. The disease is established in the Caribbean region where it threatens the American mainland. Anaplasma marginale,the agent of livestock anaplasmosis has a wider distribution. It has been identified on all continents where it is transmitted by ticks and biting flies. Both diseases are classified in list B of Office International des Epizooties. Their presence in a country is an obstacle to international trade of animals and losses induced constitute a major constraint to increased productivity of livestock. The objective of the project is to contribute to increased productivity of livestock by controlling the diseases in a context of sustainable production systems and environmental safety. To do so, integrated control is necessary where specific diagnostic and efficient vaccines are essential to reduce the use of acaricides which raise environment and food safety issues. This aim of the project is to deliver improved vaccines, diagnostic tests, risk mapping and economic analysis of vaccine control. Resuts will be obtained by extensive use of modern genomics: annotation, comparative and functional genomics of vector-pathogen interaction aiming to identify genes candidates. After refinement of the protective immune responses analysis, these candidates will be analysed in vitro and on ruminants for their ability to provide protection. New delivery systems and formulations will be applied to these candidates and evaluated for their ability to provide the best protection in a potential field vaccine. Meanwhile, molecular diagnostic (detection and genotyping) will allow us to establish a regional distribution and risk map to help decision-making in sanitary interventions and as a basis for cost-benefit studies of vaccination.

Appel à propositions

FP6-2002-INCO-DEV-1
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Coordinateur

CENTRE DE COOPERATION INTERNATIONAL EN RECHERCHE AGRONOMIQUE POUR LE DEVELOPPEMENT
Adresse
42, Rue Scheffer
Paris
France

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Participants (10)

THE UNIVERSITY OF EDINBURGH
United Kingdom
Adresse
Old College, South Bridge
Edinburgh

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UTRECHT UNIVERSITY
Pays-Bas
Adresse
Heidelberglaan 8
Utrecht

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INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA
Portugal
Adresse
Av. Da República - Ean - Qta. Do Marquês
Oeiras

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CENTRE DE RECHERCHE-DEVELOPPEMENT SUR L ELEVAGE EN ZONE SUB-HUMIDE
Burkina
Adresse
5-31 Angle Avenue Du Gouverneur Louveau
Bobo-dioulasso

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MAKERERE UNIVERSITY
Ouganda
Adresse
Makerere Hill Road
Kampala

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INTERNATIONAL TRYPANOTOLERANCE CENTRE
Gambie
Adresse
No Name
Banjul

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INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA
Argentine
Adresse
Los Reseros Y Las Cabañas
Castelar Buenos Aires

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AGRICULTURAL RESEARCH COUNCIL / ONDERSTEPOORT VETERINARY INSTITUTE
Afrique du Sud
Adresse
Old Soutpan Road
Onderstepoort

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INSTITUT SENEGALAIS DE RECHERCHES AGRICOLES
Sénégal
Adresse
Route Des Hydrocarbures
Dakar-hann

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UNIVERSITÄT BERN
Suisse
Adresse
Hochschulstr. 4
Bern

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