Objectif Heartwater or cowdriosis is a rickettsial disease of wild and domestic ruminants caused by Ehrlichia ruminantium. It occurs in sub-saharan Africa,Madagascar and the surrounding islands where the Amblyomma vectors are distributed. The disease is established in the Caribbean region where it threatens the American mainland. Anaplasma marginale,the agent of livestock anaplasmosis has a wider distribution. It has been identified on all continents where it is transmitted by ticks and biting flies. Both diseases are classified in list B of Office International des Epizooties. Their presence in a country is an obstacle to international trade of animals and losses induced constitute a major constraint to increased productivity of livestock. The objective of the project is to contribute to increased productivity of livestock by controlling the diseases in a context of sustainable production systems and environmental safety. To do so, integrated control is necessary where specific diagnostic and efficient vaccines are essential to reduce the use of acaricides which raise environment and food safety issues. This aim of the project is to deliver improved vaccines, diagnostic tests, risk mapping and economic analysis of vaccine control. Resuts will be obtained by extensive use of modern genomics: annotation, comparative and functional genomics of vector-pathogen interaction aiming to identify genes candidates. After refinement of the protective immune responses analysis, these candidates will be analysed in vitro and on ruminants for their ability to provide protection. New delivery systems and formulations will be applied to these candidates and evaluated for their ability to provide the best protection in a potential field vaccine. Meanwhile, molecular diagnostic (detection and genotyping) will allow us to establish a regional distribution and risk map to help decision-making in sanitary interventions and as a basis for cost-benefit studies of vaccination. Champ scientifique sciences médicales et de la santémédecine fondamentaleimmunologieimmunisationsciences médicales et de la santésciences de la santésanté publique et environnementaleépidémiologiesciences médicales et de la santémédecine fondamentalepharmacologie et pharmacieproduit pharmaceutiquevaccinssciences agricolessciences animales et liées à l'industrie laitièreanimaux domestiqueszootechniesciences naturellessciences biologiquesgénétiquegénome Programme(s) FP6-INCO - Specific measures in support of international cooperation: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) INCO-2002-A3.1 - Health of livestock populations Appel à propositions FP6-2002-INCO-DEV-1 Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur CENTRE DE COOPERATION INTERNATIONAL EN RECHERCHE AGRONOMIQUE POUR LE DEVELOPPEMENT Adresse 42, rue scheffer Paris France Voir sur la carte Liens Site web Opens in new window Contribution de l’UE € 0,00 Participants (10) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire THE UNIVERSITY OF EDINBURGH Royaume-Uni Contribution de l’UE € 0,00 Adresse Old college, south bridge Edinburgh Voir sur la carte Liens Site web Opens in new window UTRECHT UNIVERSITY Pays-Bas Contribution de l’UE € 0,00 Adresse Heidelberglaan 8 Utrecht Voir sur la carte Liens Site web Opens in new window INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA Portugal Contribution de l’UE € 0,00 Adresse Av. da república - ean - qta. do marquês Oeiras Voir sur la carte Liens Site web Opens in new window CENTRE DE RECHERCHE-DEVELOPPEMENT SUR L ELEVAGE EN ZONE SUB-HUMIDE Burkina Contribution de l’UE € 0,00 Adresse 5-31 angle avenue du gouverneur louveau Bobo-dioulasso Voir sur la carte Liens Site web Opens in new window MAKERERE UNIVERSITY Ouganda Contribution de l’UE € 0,00 Adresse Makerere hill road Kampala Voir sur la carte Liens Site web Opens in new window INTERNATIONAL TRYPANOTOLERANCE CENTRE Gambie Contribution de l’UE € 0,00 Adresse No name Banjul Voir sur la carte Liens Site web Opens in new window INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA Argentine Contribution de l’UE € 0,00 Adresse Los reseros y las cabañas Castelar buenos aires Voir sur la carte Liens Site web Opens in new window AGRICULTURAL RESEARCH COUNCIL / ONDERSTEPOORT VETERINARY INSTITUTE Afrique du Sud Contribution de l’UE € 0,00 Adresse Old soutpan road Onderstepoort Voir sur la carte Liens Site web Opens in new window INSTITUT SENEGALAIS DE RECHERCHES AGRICOLES Sénégal Contribution de l’UE € 0,00 Adresse Route des hydrocarbures Dakar-hann Voir sur la carte Liens Site web Opens in new window UNIVERSITÄT BERN Suisse Contribution de l’UE € 0,00 Adresse Hochschulstr. 4 Bern Voir sur la carte Liens Site web Opens in new window
