Objective
The aim is to contribute to improvement of livestock productivity in DC through limitation of trypanosome-associated pathology and accurate diagnostics of trypanosome infections. It is proposed to develop immunisation strategies against pathogenic factors of trypanosomes (anti-disease vaccine). In a previous INCO project we focused on congopain, an immunosuppressive cysteine protease (CP) of Trypanosoma congolense. As the effects of immunisation with congopain are limited, association with other antigens is required. The current proposals expand the initial work to screening and characterisation of other pathogenic molecules, especially those responsible for anaemia. A number of other trypanosome proteases - CPs, serine and metallo- proteases - require characterisation as to their biological roles in the parasite and the host. Trypanosomes also contain protease inhibitors, some of which have immunomodulatory effects. They may thus be manipulated, directly or in association with their partner enzymes, to modulate the disease. Other, non-proteolytic, factors have been identified. The GPI (glycosyl phosphatidyl inositol) anchor of the T. brucei Variant Surface Glycoprotein is a major inducer of TNF, a cytokine that mediates anaemia. Finally, recent development in the field of proteomics and progress in the genome mapping of trypanosomes provide tools to study new pathogenic pathways. In order to improve diagnosis of the disease, procedures for antibody detection will be developed and/or validated. They are based on recombinant technology, which circumvent problems associated with the current use of parasite extracts. Recombinant and synthetic peptides from CPs and heat shock proteins, both previously identified as major antigens, as well as newly described molecules, will be assessed for their diagnostic potential. Techniques for detection of parasite antigens in the host tissues will be re-examined using recently developed monoclonal antibodies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology immunisation
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine pathology
- medical and health sciences clinical medicine hematology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-INCO-DEV-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.