Skip to main content

The role of chromosome stability in persistence, latency and reactivation of mycobacterium tuberculosis

Objective

Tuberculosis causes more deaths than almost any other infectious agent, with nearly 2 million deaths each year. One-third of the world's population is latently infected with the causative agent, Mycobacterium tuberculosis. The ability of M. tuberculosis to enter into a latent state is thought to be the reason for the prolonged period of treatment required to prevent relapse, since drugs currently available mainly target actively growing bacteria.

The vast pool of latently infected individuals is a constant source of disease and transmission, as factors weakening the immune response, such as HIV infection, lead to the emergence of active disease and infection with TB is a significant cause of AIDS-associated mortality in developing countries. This project suggests to tackle the problem of latency by focusing on the mechanisms that govern chromosome integrity. There is evidence that M. tuberculosis is exposed to DNA-damaging conditions in the host during latent infection.

Field of science

  • /medical and health sciences/health sciences/public and environmental health/epidemics prevention/immunisation
  • /natural sciences/biological sciences/genetics and heredity/chromosome
  • /medical and health sciences/clinical medicine/pneumology/tuberculosis

Call for proposal

FP6-2005-LIFESCIHEALTH-6
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

UNIVERSITÄT ZÜRICH
Address
Ramistrasse 71
Zurich
Switzerland

Participants (4)

EURELATIONS AG
Switzerland
Address
Technoparkstrasse 1
Zurich
INDIAN INSTITUTE OF SCIENCE
India
Address
Sir C.v. Raman Avenue
Bangalore
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20 Park Crescent
London
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italy
Address
Via Duomo 6
Vercelli