Objective
High throughput cloning and expression of large sets of genomic ORFs has become a preferred industrial strategy for genome-wide searches of new vaccine candidates. For invasive infections in particular, the aim is to find proteins eliciting antibodies capable of binding to the bacterial cell surface and, through interaction with the complement system, effectively kill the bacteria. However, current data accumulating from reverse vaccinology studies show that only a small fraction of surface-exposed proteins appears to elicit antibodies with bactericidal activity. By using information generated by reverse vaccinology projects within the Consortium the BacAbs project will apply a novel multidisciplinary approach to single out the structural requirements for viable bactericidal vaccine candidates, and will develop bioinformatics tools to predict compliance with such structural requirements. To this end, a systematic analysis of sequence, structure, dynamics and interactions of selected protein targets will be undertaken using as model system serogroup-B Neisseria meningitidis, a pathogen causing septicemia and meningitis, for which no effective vaccine exists.
The Consortium comprises an industrial partner with extensive experience on vaccine development, three SMEs with strong expertises on several of the key technological aspects of the project, and five academic partners with internationally recognised tracks on experimental and theoretical studies of protein structure and interactions. By focusing on meningococcal vaccine development, the project can deliver information (knowledge) relevant to Life Sciences and Human Health and provide new tools and improved methods (technology) of potential application to research on other pathogens at the genomic level. BacAbs meets the scientific and organizational criteria for topic LSH-2005-1.2.4-7. In addition, it has strong links to LSH-2005-2.1.2-5 and LSH-2005-1.2.5-4.
Fields of science (EuroSciVoc)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
- LSH-2005-1.2.4-7 - Development and testing of new preventive and therapeutic tools, such as somatic gene and cell therapies (in particular stem cell therapies, for example those on neurological and neuromuscular disorders) and immunotherapies
- LSH-2005-2.1.2-5 - Development of novel principles for anti-microbial treatment
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BELLATERRA (CERDANYOLA DEL VALLÈS)
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.