Objective
The objective of FLUOROMAG will be to
(a) produce noble metal nanoclusters or nanodots, (NDs), and core-shell (CSs) nanoparticles by a new method using controlled electrochemical techniques that ensure very uniform size distributions and transfer of this technology to a dedicated SME who will scale up the synthesis of these nanoparticles for commercial production as well as supply the consortium with NPs for characterization of their extinction, fluorescent and magnetic properties and the further development of diagnostic tests.
(b) devise conjugation strategies to couple biomolecules to noble metal NDs and commercially available quantum dots, (QDs) to produce probes that can specifically target macromolecules such as proteins and DNA/RNA in vitro and in cells and tissues. We will take advantage of ND electrochemical synthesis to introduce specific molecules in the shells that permit efficient derivatization and coupling to biomolecules.
(c) develop multiparametric diagnostic assays using combinations of bioconjugated QDs and noble metal NDs as novel, fluorescent probes, and bioconjugated noble metal nanoparticles as extinction probes. The goal is to achieve high sensitivity (down to single virus detection) in molecular and cellular recognition. New Hepatitis C, Dengue Fever and breast tumor assays are proposed that will monitor several antigens in multiplexed kinetic and end-point determinations.
(d) develop a commercial, low-cost programmable array microscope (PAM) module for wide field microscopes with SME partner which utilizes a spatial light modulator to achieve high-speed sectioning and simultaneous measurement of multiple fluorescence modalities as a detection system for single and multiplexed diagnostic assays using nanoparticles developed in a-c for the health-care market.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MUENCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.