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Pathophysiology of the cartilage growth plate

Objective

The chondrodysplasias are an extremely diverse and complex group of rare genetic disorders, which affect the development of the skeleton. There are over 200 unique and well-characterised phenotypes, which range in severity from relatively mild to severe and lethal forms. They have an overall prevalence of at least 4 per 10,000 and this extrapolates to a minimum of 178,000 people in the 25 member states that suffer from chondrodysplasia.

Many of the individual skeletal dysplasia phenotypes have been grouped into 'bone dysplasia families' on the basis of similar clinical and radiographic features and it has been proposed that members of the same family will share a common disease pathophysiology. Therefore, as a group of heterogeneous diseases, the chondrodysplasias have a complex aetiology but are likely to share similar basic mechanisms of disease initiation, progression and end-stage pathology.

Call for proposal

FP6-2005-LIFESCIHEALTH-6
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Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

THE UNIVERSITY OF MANCHESTER
Address
Oxford Road
Manchester
United Kingdom

Participants (10)

UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Address
6 Kensington Terrace
Newcastle Upon Tyne
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V
Germany
Address
Hofgartenstrasse 8 80539 Muenchen Germany
Berlin
MURDOCH CHILDRENS RESEARCH INSTITUTE
Australia
Address
Royal Children's Hospital, Flemington Road
Parkville, Victoria
UNIVERSITEIT GENT
Belgium
Address
Sint-pietersnieuwstraat 25
Gent
CERTUS TECHNOLOGY ASSOCIATES LIMITED
United Kingdom
Address
Reg. Offices: 9 Abbey Road
Exeter
GENTERPRISE GESELLSCHAFT FUER GENANALYSE UND BIOTECHNOLOGIE M. B. H.
Germany
Address
Johann-joachim-becherweg 32
Mainz
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS
Spain
Address
Calle Serrano 117
Madrid
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101 Rue De Tolbiac
Paris
UNIVERSITÀ DEGLI STUDI DI PAVIA
Italy
Address
Corso Strada Nuova, 65
Pavia
UNIVERSITÄTSKLINIKUM FREIBURG
Germany
Address
Hugstetter Str. 55
Freiburg