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Systemic Amyloidoses in Europe

Objective

The systemic amyloidoses is a heterogeneous group of diseases, all characterized by deposition in many tissues and organs of a principally extracellular, pathological substance, called amyloid. The amyloid is an insoluble, fibrillar form of one of more than 25 normally soluble proteins. The fibril protein in the amyloid is more or less misfolded and contains an unusually high degree of beta-sheet, allowing molecules to assemble into long, rigid and resistant fibrils. The pathogenesis is still unclear but overproduction of the amyloidogenic protein and destabilization of the tertiary structure by mutations is often involved.

The general aim of this proposal is to use recently obtained knowledge of the human genome and its products to understand the nature of systemic amyloidoses. The aim is also to translate this basic knowledge on proteins, protein folding and protein interaction into the clinical situation in order to develop safe diagnostic methods and new treatments for this group of usually deadly diseases. This will be done by a collective effort of a group of European scientists, covering the whole field from molecular mechanisms to clinicians devoted to treatment of patients with systemic amyloidosis. Basic studies will performed with advanced biochemical and biophysical methods including e.g. plasmon-resonance-based techniques and nuclear magnetic resonance (NMR) spectroscopy.

Knowledge from basic studies will be translated into biological systems in order to elucidate mechanisms by which aggregated proteins are deleterious to cells and for these studies, cell cultures and transgenic organisms (mice, Drosophila) will be used. These systems will also be used for development of evaluation of methods to interfere with development of amyloid. The mutual effort also aims to increase the general awareness of the systemic amyloidoses, today often diagnosed late in disease, and to further develop simple and safe diagnostic methods.

Call for proposal

FP6-2005-LIFESCIHEALTH-6
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

UPPSALA UNIVERSITET
Address
Sankt Olofsgatan 10B
Uppsala
Sweden

Participants (12)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge
ISTITUTO NAZIONALE BIOSTRUTTURE E BIOSISTEMI
Italy
Address
Viale Delle Medaglie D'oro, 305
Roma
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London
FONDAZIONE IRCCS POLICLINICO SAN MATTEO
Italy
Address
Viale Golgi, 19
Pavia
INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR - IBMC
Portugal
Address
Rua Do Campo Alegre 823
Porto
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
Address
Hanzeplein 1
Groningen
CHARITÉ-UNIVERSITÄTSMEDIZIN BERLIN
Germany
Address
Schumannstr. 20/21
Berlin
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MÉDICALE
France
Address
101 R Tolbiac
Paris
LINKÖPING UNIVERSITET
Sweden
Address
Hus Origo Campus Valla
Linköping
UMEÅ UNIVERSITET
Sweden
Address
Not Given.
Umeå
UNIVERSITÉ DE LIMOGES
France
Address
2 Rue Du Docteur Marcland
Limoges
UNIVERSITÉ DE LIÈGE
Belgium
Address
Place Du 20 Aout, 7
Liege